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10.1093/infdis/jiab195

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suck abstract from ncbi


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pmid33837392      J+Infect+Dis 2021 ; 223 (11): 1842-1854
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  • Broad Severe Acute Respiratory Syndrome Coronavirus 2 Cell Tropism and Immunopathology in Lung Tissues From Fatal Coronavirus Disease 2019 #MMPMID33837392
  • Ramos da Silva S; Ju E; Meng W; Paniz Mondolfi AE; Dacic S; Green A; Bryce C; Grimes Z; Fowkes M; Sordillo EM; Cordon-Cardo C; Guo H; Gao SJ
  • J Infect Dis 2021[Jun]; 223 (11): 1842-1854 PMID33837392show ga
  • BACKGROUND: Coronavirus disease 2019 (COVID-19) patients manifest with pulmonary symptoms reflected by diffuse alveolar damage (DAD), excessive inflammation, and thromboembolism. The mechanisms mediating these processes remain unclear. METHODS: We performed multicolor staining for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins and lineage markers to define viral tropism and lung pathobiology in 5 autopsy cases. RESULTS: Lung parenchyma showed severe DAD with thromboemboli. Viral infection was found in an extensive range of cells including pneumocyte type II, ciliated, goblet, club-like, and endothelial cells. More than 90% of infiltrating immune cells were positive for viral proteins including macrophages, monocytes, neutrophils, natural killer (NK) cells, B cells, and T cells. Most but not all infected cells were angiotensin-converting enzyme 2 (ACE2) positive. The numbers of infected and ACE2-positive cells are associated with extensive tissue damage. Infected tissues exhibited high levels of inflammatory cells including macrophages, monocytes, neutrophils, and NK cells, and low levels of B cells but abundant T cells consisting of mainly T helper cells, few cytotoxic T cells, and no regulatory T cells. Robust interleukin-6 expression was present in most cells, with or without infection. CONCLUSIONS: In fatal COVID-19 lungs, there are broad SARS-CoV-2 cell tropisms, extensive infiltrated innate immune cells, and activation and depletion of adaptive immune cells, contributing to severe tissue damage, thromboemboli, excess inflammation, and compromised immune responses.
  • |*Viral Tropism/immunology[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/immunology/*pathology/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |Lung/cytology/immunology/*pathology/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pulmonary Alveoli/immunology/pathology/virology[MESH]


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