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10.1038/s41541-021-00307-6 http://scihub22266oqcxt.onion/10.1038/s41541-021-00307-6 33837212!8035178!33837212     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33837212&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       NPJ+Vaccines 2021 ; 6 (1): 50 Nephropedia Template TP {{tp|p=33837212|t=2021. Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates |pdf=|usr=}}{{33837212}} gab.com Text Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates JO: NPJ Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=33837212 #FOAvip The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of immunization against infectious diseases in preclinical studies, and are being tested for SARS-CoV-2 in humans. A critical question is how mRNA-LNP vaccine immunogenicity compares to that of traditional adjuvanted protein vaccines in primates. Here, we show that mRNA-LNP immunization compared to protein immunization elicits either the same or superior magnitude and breadth of HIV-1 Env-specific polyfunctional antibodies. Immunization with mRNA-LNP encoding Zika premembrane and envelope or HIV-1 Env gp160 induces durable neutralizing antibodies for at least 41 weeks. Doses of mRNA-LNP as low as 5 mug are immunogenic in macaques. Thus, mRNA-LNP can be used to rapidly generate single or multi-component vaccines, such as sequential vaccines needed to protect against HIV-1 infection. Such vaccines would be as or more immunogenic than adjuvanted recombinant protein vaccines in primates. Twit Text FOAVip Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates ????NPJ Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=33837212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33837212 #FOAvip English Wikipedia <ref>{{Cite pmid|33837212}}</ref> Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates #MMPMID33837212 Saunders KO; Pardi N; Parks R; Santra S; Mu Z; Sutherland L; Scearce R; Barr M; Eaton A; Hernandez G; Goodman D; Hogan MJ; Tombacz I; Gordon DN; Rountree RW; Wang Y; Lewis MG; Pierson TC; Barbosa C; Tam Y; Matyas GR; Rao M; Beck Z; Shen X; Ferrari G; Tomaras GD; Montefiori DC; Weissman D; Haynes BF NPJ Vaccines 2021[Apr]; 6 (1): 50 PMID33837212show ga The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of immunization against infectious diseases in preclinical studies, and are being tested for SARS-CoV-2 in humans. A critical question is how mRNA-LNP vaccine immunogenicity compares to that of traditional adjuvanted protein vaccines in primates. Here, we show that mRNA-LNP immunization compared to protein immunization elicits either the same or superior magnitude and breadth of HIV-1 Env-specific polyfunctional antibodies. Immunization with mRNA-LNP encoding Zika premembrane and envelope or HIV-1 Env gp160 induces durable neutralizing antibodies for at least 41 weeks. Doses of mRNA-LNP as low as 5 mug are immunogenic in macaques. Thus, mRNA-LNP can be used to rapidly generate single or multi-component vaccines, such as sequential vaccines needed to protect against HIV-1 infection. Such vaccines would be as or more immunogenic than adjuvanted recombinant protein vaccines in primates. ?Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elic(epmc).pdf DeepDyve Pubget Overpricing