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10.1038/s41467-021-22351-5 http://scihub22266oqcxt.onion/10.1038/s41467-021-22351-5 33837204!8035181!33837204     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33837204&cmd=llinks): Failed to open stream: HTTP request failed! 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Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies from a population-based study in Bonn, Germany |pdf=|usr=}}{{33837204}} gab.com Text Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies from a population-based study in Bonn, Germany JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33837204 #FOAvip To estimate the seroprevalence and temporal course of SARS-CoV-2 neutralizing antibodies, we embedded a multi-tiered seroprevalence survey within an ongoing community-based cohort study in Bonn, Germany. We first assessed anti-SARS-CoV-2 immunoglobulin G levels with an immunoassay, followed by confirmatory testing of borderline and positive test results with a recombinant spike-based immunofluorescence assay and a plaque reduction neutralization test (PRNT). Those with a borderline or positive immunoassay result were retested after 4 to 5 months. At baseline, 4771 persons participated (88% response rate). Between April 24(th) and June 30(th), 2020, seroprevalence was 0.97% (95% CI: 0.72-1.30) by immunoassay and 0.36% (95% CI: 0.21-0.61) when considering only those with two additional positive confirmatory tests. Importantly, about 20% of PRNT+ individuals lost their neutralizing antibodies within five months. Here, we show that neutralizing antibodies are detectable in only one third of those with a positive immunoassay result, and wane relatively quickly. Twit Text FOAVip Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies from a population-based study in Bonn, Germany ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33837204 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33837204 #FOAvip English Wikipedia <ref>{{Cite pmid|33837204}}</ref> Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies from a population-based study in Bonn, Germany #MMPMID33837204 Aziz NA; Corman VM; Echterhoff AKC; Muller MA; Richter A; Schmandke A; Schmidt ML; Schmidt TH; de Vries FM; Drosten C; Breteler MMB Nat Commun 2021[Apr]; 12 (1): 2117 PMID33837204show ga To estimate the seroprevalence and temporal course of SARS-CoV-2 neutralizing antibodies, we embedded a multi-tiered seroprevalence survey within an ongoing community-based cohort study in Bonn, Germany. We first assessed anti-SARS-CoV-2 immunoglobulin G levels with an immunoassay, followed by confirmatory testing of borderline and positive test results with a recombinant spike-based immunofluorescence assay and a plaque reduction neutralization test (PRNT). Those with a borderline or positive immunoassay result were retested after 4 to 5 months. At baseline, 4771 persons participated (88% response rate). Between April 24(th) and June 30(th), 2020, seroprevalence was 0.97% (95% CI: 0.72-1.30) by immunoassay and 0.36% (95% CI: 0.21-0.61) when considering only those with two additional positive confirmatory tests. Importantly, about 20% of PRNT+ individuals lost their neutralizing antibodies within five months. Here, we show that neutralizing antibodies are detectable in only one third of those with a positive immunoassay result, and wane relatively quickly. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/*diagnosis/prevention & control/virology[MESH] |Cohort Studies[MESH] |Female[MESH] |Germany[MESH] |Humans[MESH] |Immunoassay/methods[MESH] |Immunoglobulin G/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Neutralization Tests/methods[MESH] |Population Surveillance/methods[MESH] |SARS-CoV-2/*immunology/physiology[MESH]Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies fr(epmc).pdf DeepDyve Pubget Overpricing