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10.1016/j.intimp.2021.107615 http://scihub22266oqcxt.onion/10.1016/j.intimp.2021.107615 33836368!8023047!33836368     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2021 ; 96 (ä): 107615 Nephropedia Template TP {{tp|p=33836368|t=2021. Identification of COVID-19 subtypes based on immunogenomic profiling |pdf=|usr=}}{{33836368}} gab.com Text Identification of COVID-19 subtypes based on immunogenomic profiling JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33836368 #FOAvip Although previous studies have shown that the host immune response is crucial in determining clinical outcomes in COVID-19 patients, the association between host immune signatures and COVID-19 patient outcomes remains unclear. Based on the enrichment levels of 11 immune signatures (eight immune-inciting and three immune-inhibiting signatures) in leukocytes of 100 COVID-19 patients, we identified three COVID-19 subtypes: Im-C1, Im-C2, and Im-C3, by clustering analysis. Im-C1 had the lowest immune-inciting signatures and high immune-inhibiting signatures. Im-C2 had medium immune-inciting signatures and high immune-inhibiting signatures. Im-C3 had the highest immune-inciting signatures while the lowest immune-inhibiting signatures. Im-C3 and Im-C1 displayed the best and worst clinical outcomes, respectively, suggesting that antiviral immune responses alleviated the severity of COVID-19 patients. We further demonstrated that the adaptive immune response had a stronger impact on COVID-19 outcomes than the innate immune response. The patients in Im-C3 were younger than those in Im-C1, indicating that younger persons have stronger antiviral immune responses than older persons. Nevertheless, we did not observe a significant association between sex and immune responses in COVID-19 patients. In addition, we found that the type II IFN response signature was an adverse prognostic factor for COVID-19. Our identification of COVID-19 immune subtypes has potential clinical implications for the management of COVID-19 patients. Twit Text FOAVip Identification of COVID-19 subtypes based on immunogenomic profiling ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33836368 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33836368 #FOAvip English Wikipedia <ref>{{Cite pmid|33836368}}</ref> Identification of COVID-19 subtypes based on immunogenomic profiling #MMPMID33836368 Chen Z; Feng Q; Zhang T; Wang X Int Immunopharmacol 2021[Jul]; 96 (ä): 107615 PMID33836368show ga Although previous studies have shown that the host immune response is crucial in determining clinical outcomes in COVID-19 patients, the association between host immune signatures and COVID-19 patient outcomes remains unclear. Based on the enrichment levels of 11 immune signatures (eight immune-inciting and three immune-inhibiting signatures) in leukocytes of 100 COVID-19 patients, we identified three COVID-19 subtypes: Im-C1, Im-C2, and Im-C3, by clustering analysis. Im-C1 had the lowest immune-inciting signatures and high immune-inhibiting signatures. Im-C2 had medium immune-inciting signatures and high immune-inhibiting signatures. Im-C3 had the highest immune-inciting signatures while the lowest immune-inhibiting signatures. Im-C3 and Im-C1 displayed the best and worst clinical outcomes, respectively, suggesting that antiviral immune responses alleviated the severity of COVID-19 patients. We further demonstrated that the adaptive immune response had a stronger impact on COVID-19 outcomes than the innate immune response. The patients in Im-C3 were younger than those in Im-C1, indicating that younger persons have stronger antiviral immune responses than older persons. Nevertheless, we did not observe a significant association between sex and immune responses in COVID-19 patients. In addition, we found that the type II IFN response signature was an adverse prognostic factor for COVID-19. Our identification of COVID-19 immune subtypes has potential clinical implications for the management of COVID-19 patients. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*classification/*immunology[MESH] |Cluster Analysis[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH]Identification of COVID-19 subtypes based on immunogenomic profiling (epmc).pdf DeepDyve Pubget Overpricing