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10.1089/bfm.2020.0381

http://scihub22266oqcxt.onion/10.1089/bfm.2020.0381
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33835835!ä!33835835

suck abstract from ncbi


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pmid33835835      Breastfeed+Med 2021 ; 16 (5): 393-401
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  • Comparison of Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies Binding Capacity Between Human Milk and Serum from Coronavirus Disease 2019-Recovered Women #MMPMID33835835
  • Demers-Mathieu V; DaPra C; Medo E
  • Breastfeed Med 2021[May]; 16 (5): 393-401 PMID33835835show ga
  • Background: Human milk from coronavirus disease 2019 (COVID-19)-recovered women may be useful as oral antibody therapy to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and provide long-term immunity to neonates and young children. As convalescent plasma is already used as antibody therapy, this study aimed to compare the binding capacity of antibodies specific to the receptor-binding domain (RBD) of SARS-CoV-2 between human milk and serum from COVID-19-recovered women. Materials and Methods: The areas under the curve (AUCs) for IgA, IgM, and IgG specific to the SARS-CoV-2 RBD in human milk and serum samples were measured using enzyme-linked immunosorbent assay. Milk samples were collected from 12 COVID-19-recovered women, while serum samples were from 10 COVID-19-recovered women. The antibody concentrations were also determined. Results: Our study reveals that SARS-CoV-2 RBD-specific antibody titers differed between human milk and serum samples from COVID-19-recovered women. When the AUCs were not divided by the antibody concentration, SARS-CoV-2 RBD-specific IgA, IgM, and IgG levels were higher in the serum sample group than the human milk group (p < 0.001). However, the titers of SARS-CoV-2 RBD-specific IgM (AUC/mug of IgM) and IgG (AUC/mug of IgG) were higher in human milk samples than serum samples (p < 0.05). The titer of SARS-CoV-2 RBD-specific IgA (AUC/mg of IgA) was higher in the serum sample group than the human milk group (p < 0.01). Conclusions: Human milk antibodies specific to the RBD of SARS-CoV-2 must be purified to obtain comparable binding capacity observed with SARS-CoV-2 RBD-specific serum antibodies.
  • |*Milk, Human/metabolism[MESH]
  • |*SARS-CoV-2[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |Breast Feeding[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19/*therapy[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Immunoglobulin G[MESH]
  • |Infant, Newborn[MESH]


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