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10.1056/NEJMoa2104882

http://scihub22266oqcxt.onion/10.1056/NEJMoa2104882
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33835768!8112568!33835768
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suck abstract from ncbi


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pmid33835768      N+Engl+J+Med 2021 ; 384 (22): 2124-2130
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  • Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination #MMPMID33835768
  • Schultz NH; Sorvoll IH; Michelsen AE; Munthe LA; Lund-Johansen F; Ahlen MT; Wiedmann M; Aamodt AH; Skattor TH; Tjonnfjord GE; Holme PA
  • N Engl J Med 2021[Jun]; 384 (22): 2124-2130 PMID33835768show ga
  • We report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). The patients were health care workers who were 32 to 54 years of age. All the patients had high levels of antibodies to platelet factor 4-polyanion complexes; however, they had had no previous exposure to heparin. Because the five cases occurred in a population of more than 130,000 vaccinated persons, we propose that they represent a rare vaccine-related variant of spontaneous heparin-induced thrombocytopenia that we refer to as vaccine-induced immune thrombotic thrombocytopenia.
  • |Adult[MESH]
  • |Autoantibodies/*blood[MESH]
  • |Autoimmune Diseases/etiology[MESH]
  • |Blood Chemical Analysis[MESH]
  • |COVID-19 Vaccines/*adverse effects[MESH]
  • |ChAdOx1 nCoV-19[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Fatal Outcome[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Platelet Aggregation[MESH]
  • |Platelet Count[MESH]
  • |Platelet Factor 4/*immunology[MESH]
  • |Thrombocytopenia/*etiology[MESH]


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