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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Transplant 2021 ; 21 (8): 2876-2884 Nephropedia Template TP
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Changes in humoral immune response after SARS-CoV-2 infection in liver transplant recipients compared to immunocompetent patients #MMPMID33835707
Caballero-Marcos A; Salcedo M; Alonso-Fernandez R; Rodriguez-Peralvarez M; Olmedo M; Graus Morales J; Cuervas-Mons V; Cachero A; Loinaz-Segurola C; Inarrairaegui M; Castells L; Pascual S; Vinaixa-Aunes C; Gonzalez-Grande R; Otero A; Tome S; Tejedor-Tejada J; Alamo-Martinez JM; Gonzalez-Dieguez L; Nogueras-Lopez F; Blanco-Fernandez G; Munoz-Bartolo G; Bustamante FJ; Fabrega E; Romero-Cristobal M; Martin-Mateos R; Del Rio-Izquierdo J; Arias-Milla A; Calatayud L; Marcacuzco-Quinto AA; Fernandez-Alonso V; Gomez-Gavara C; Colmenero J; Munoz P; Pons JA
Am J Transplant 2021[Aug]; 21 (8): 2876-2884 PMID33835707show ga
The protective capacity and duration of humoral immunity after SARS-CoV-2 infection are not yet understood in solid organ transplant recipients. A prospective multicenter study was performed to evaluate the persistence of anti-nucleocapsid IgG antibodies in liver transplant recipients 6 months after coronavirus disease 2019 (COVID-19) resolution. A total of 71 liver transplant recipients were matched with 71 immunocompetent controls by a propensity score including variables with a well-known prognostic impact in COVID-19. Paired case-control serological data were also available in 62 liver transplant patients and 62 controls at month 3 after COVID-19. Liver transplant recipients showed a lower incidence of anti-nucleocapsid IgG antibodies at 3 months (77.4% vs. 100%, p < .001) and at 6 months (63.4% vs. 90.1%, p < .001). Lower levels of antibodies were also observed in liver transplant patients at 3 (p = .001) and 6 months (p < .001) after COVID-19. In transplant patients, female gender (OR = 13.49, 95% CI: 2.17-83.8), a longer interval since transplantation (OR = 1.19, 95% CI: 1.03-1.36), and therapy with renin-angiotensin-aldosterone system inhibitors (OR = 7.11, 95% CI: 1.47-34.50) were independently associated with persistence of antibodies beyond 6 months after COVID-19. Therefore, as compared with immunocompetent patients, liver transplant recipients show a lower prevalence of anti-SARS-CoV-2 antibodies and more pronounced antibody levels decline.