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10.1051/medsci/2021021

http://scihub22266oqcxt.onion/10.1051/medsci/2021021
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33835019!ä!33835019

suck abstract from ncbi


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pmid33835019      Med+Sci+(Paris) 2021 ; 37 (4): 333-341
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  • Implication de la cascade du complement dans les formes severes de COVID-19 #MMPMID33835019
  • Chouaki Benmansour N; Carvelli J; Vivier E
  • Med Sci (Paris) 2021[Apr]; 37 (4): 333-341 PMID33835019show ga
  • The complement system is an essential component of the innate immune system. Its excessive activation during COVID-19 contributes to cytokine storm, disease-specific endothelial inflammation (endotheliitis) and thrombosis that comes with the disease. Targeted therapies of complement inhibition in COVID-19, in particular blocking the C5a-C5aR1 axis have to be taken into account in the establishment of potential biomarkers and development of therapeutic strategies in the most severe forms of the disease.
  • |Animals[MESH]
  • |COVID-19/*immunology/metabolism/*pathology[MESH]
  • |Complement Activation/*physiology[MESH]
  • |Complement C5a/immunology/metabolism[MESH]
  • |Complement System Proteins/*physiology[MESH]
  • |Cytokine Release Syndrome/etiology/immunology/pathology[MESH]
  • |Humans[MESH]
  • |Inflammation/complications/immunology/pathology[MESH]
  • |SARS-CoV-2/immunology[MESH]
  • |Severity of Illness Index[MESH]


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