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10.1186/s12859-021-04017-7 http://scihub22266oqcxt.onion/10.1186/s12859-021-04017-7 33832440!8027979!33832440     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Bioinformatics 2021 ; 22 (1): 182 Nephropedia Template TP {{tp|p=33832440|t=2021. Common low complexity regions for SARS-CoV-2 and human proteomes as potential multidirectional risk factor in vaccine development |pdf=|usr=}}{{33832440}} gab.com Text Common low complexity regions for SARS-CoV-2 and human proteomes as potential multidirectional risk factor in vaccine development JO: BMC Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=33832440 #FOAvip BACKGROUND: The rapid spread of the COVID-19 demands immediate response from the scientific communities. Appropriate countermeasures mean thoughtful and educated choice of viral targets (epitopes). There are several articles that discuss such choices in the SARS-CoV-2 proteome, other focus on phylogenetic traits and history of the Coronaviridae genome/proteome. However none consider viral protein low complexity regions (LCRs). Recently we created the first methods that are able to compare such fragments. RESULTS: We show that five low complexity regions (LCRs) in three proteins (nsp3, S and N) encoded by the SARS-CoV-2 genome are highly similar to regions from human proteome. As many as 21 predicted T-cell epitopes and 27 predicted B-cell epitopes overlap with the five SARS-CoV-2 LCRs similar to human proteins. Interestingly, replication proteins encoded in the central part of viral RNA are devoid of LCRs. CONCLUSIONS: Similarity of SARS-CoV-2 LCRs to human proteins may have implications on the ability of the virus to counteract immune defenses. The vaccine targeted LCRs may potentially be ineffective or alternatively lead to autoimmune diseases development. These findings are crucial to the process of selection of new epitopes for drugs or vaccines which should omit such regions. Twit Text FOAVip Common low complexity regions for SARS-CoV-2 and human proteomes as potential multidirectional risk factor in vaccine development ????BMC Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=33832440 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33832440 #FOAvip English Wikipedia <ref>{{Cite pmid|33832440}}</ref> Common low complexity regions for SARS-CoV-2 and human proteomes as potential multidirectional risk factor in vaccine development #MMPMID33832440 Gruca A; Ziemska-Legiecka J; Jarnot P; Sarnowska E; Sarnowski TJ; Grynberg M BMC Bioinformatics 2021[Apr]; 22 (1): 182 PMID33832440show ga BACKGROUND: The rapid spread of the COVID-19 demands immediate response from the scientific communities. Appropriate countermeasures mean thoughtful and educated choice of viral targets (epitopes). There are several articles that discuss such choices in the SARS-CoV-2 proteome, other focus on phylogenetic traits and history of the Coronaviridae genome/proteome. However none consider viral protein low complexity regions (LCRs). Recently we created the first methods that are able to compare such fragments. RESULTS: We show that five low complexity regions (LCRs) in three proteins (nsp3, S and N) encoded by the SARS-CoV-2 genome are highly similar to regions from human proteome. As many as 21 predicted T-cell epitopes and 27 predicted B-cell epitopes overlap with the five SARS-CoV-2 LCRs similar to human proteins. Interestingly, replication proteins encoded in the central part of viral RNA are devoid of LCRs. CONCLUSIONS: Similarity of SARS-CoV-2 LCRs to human proteins may have implications on the ability of the virus to counteract immune defenses. The vaccine targeted LCRs may potentially be ineffective or alternatively lead to autoimmune diseases development. These findings are crucial to the process of selection of new epitopes for drugs or vaccines which should omit such regions. |*Proteome[MESH] |*Sequence Homology[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Nucleocapsid Proteins/immunology[MESH] |Epitopes, B-Lymphocyte/immunology[MESH] |Epitopes, T-Lymphocyte/immunology[MESH] |Humans[MESH] |Phosphoproteins/immunology[MESH] |Phylogeny[MESH] |RNA-Dependent RNA Polymerase/immunology[MESH] |Risk Factors[MESH] |SARS-CoV-2/*genetics[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]Common low complexity regions for SARS-CoV-2 and human proteomes as po(epmc).pdf DeepDyve Pubget Overpricing