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10.1016/j.ijbiomac.2021.03.135 http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2021.03.135 33831450!8020621!33831450     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Macromol 2021 ; 182 (ä): 743-749 Nephropedia Template TP {{tp|p=33831450|t=2021. Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity |pdf=|usr=}}{{33831450}} gab.com Text Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity JO: Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=33831450 #FOAvip The development of high-end targeted drugs and vaccines against modern pandemic infections, such as COVID-19, can take a too long time that lets the epidemic spin up and harms society. However, the countermeasures must be applied against the infection in this period until the targeted drugs became available. In this regard, the non-specific, broad-spectrum anti-viral means could be considered as a compromise allowing overcoming the period of trial. One way to enhance the ability to resist the infection is to activate the nonspecific immunity using a suitable driving-up agent, such as plant polysaccharides, particularly our drug Panavir isolated from the potato shoots. Earlier, we have shown the noticeable anti-viral and anti-bacterial activity of Panavir. Here we demonstrate the pro-inflammation activity of Panavir, which four-to-eight times intensified the ATP and MIF secretion by HL-60 cells. This effect was mediated by the active phagocytosis of the Panavir particles by the cells. We hypothesized the physiological basis of the Panavir proinflammatory activity is mediated by the indol-containing compounds (auxins) present in Panavir and acting as a plant analog of serotonin. Twit Text FOAVip Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity ????Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=33831450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33831450 #FOAvip English Wikipedia <ref>{{Cite pmid|33831450}}</ref> Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity #MMPMID33831450 Stovbun SV; Kalinina TS; Zlenko DV; Kiselev AV; Litvin AA; Bukhvostov AA; Usachev SV; Kuznetsov DA Int J Biol Macromol 2021[Jul]; 182 (ä): 743-749 PMID33831450show ga The development of high-end targeted drugs and vaccines against modern pandemic infections, such as COVID-19, can take a too long time that lets the epidemic spin up and harms society. However, the countermeasures must be applied against the infection in this period until the targeted drugs became available. In this regard, the non-specific, broad-spectrum anti-viral means could be considered as a compromise allowing overcoming the period of trial. One way to enhance the ability to resist the infection is to activate the nonspecific immunity using a suitable driving-up agent, such as plant polysaccharides, particularly our drug Panavir isolated from the potato shoots. Earlier, we have shown the noticeable anti-viral and anti-bacterial activity of Panavir. Here we demonstrate the pro-inflammation activity of Panavir, which four-to-eight times intensified the ATP and MIF secretion by HL-60 cells. This effect was mediated by the active phagocytosis of the Panavir particles by the cells. We hypothesized the physiological basis of the Panavir proinflammatory activity is mediated by the indol-containing compounds (auxins) present in Panavir and acting as a plant analog of serotonin. |*Antiviral Agents/chemistry/pharmacokinetics/pharmacology[MESH] |*COVID-19 Drug Treatment[MESH] |*Drug Carriers/chemistry/pharmacokinetics/pharmacology[MESH] |*Nanoparticles/chemistry/therapeutic use[MESH] |*Polysaccharides/chemistry/pharmacology[MESH] |*Probucol/chemistry/pharmacokinetics/pharmacology[MESH] |Adolescent[MESH] |Adult[MESH] |HL-60 Cells[MESH] |Humans[MESH] |Male[MESH] |Phagocytosis/drug effects[MESH]Antiviral potential of plant polysaccharide nanoparticles actuating no(epmc).pdf DeepDyve Pubget Overpricing