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10.1016/j.cell.2021.03.027 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.03.027 33831372!7962548!33831372     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (10): 2605-2617.e18 Nephropedia Template TP {{tp|p=33831372|t=2021. SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms |pdf=|usr=}}{{33831372}} gab.com Text SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33831372 #FOAvip Many individuals mount nearly identical antibody responses to SARS-CoV-2. To gain insight into how the viral spike (S) protein receptor-binding domain (RBD) might evolve in response to common antibody responses, we studied mutations occurring during virus evolution in a persistently infected immunocompromised individual. We use antibody Fab/RBD structures to predict, and pseudotypes to confirm, that mutations found in late-stage evolved S variants confer resistance to a common class of SARS-CoV-2 neutralizing antibodies we isolated from a healthy COVID-19 convalescent donor. Resistance extends to the polyclonal serum immunoglobulins of four out of four healthy convalescent donors we tested and to monoclonal antibodies in clinical use. We further show that affinity maturation is unimportant for wild-type virus neutralization but is critical to neutralization breadth. Because the mutations we studied foreshadowed emerging variants that are now circulating across the globe, our results have implications to the long-term efficacy of S-directed countermeasures. Twit Text FOAVip SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33831372 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33831372 #FOAvip English Wikipedia <ref>{{Cite pmid|33831372}}</ref> SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms #MMPMID33831372 Clark SA; Clark LE; Pan J; Coscia A; McKay LGA; Shankar S; Johnson RI; Brusic V; Choudhary MC; Regan J; Li JZ; Griffiths A; Abraham J Cell 2021[May]; 184 (10): 2605-2617.e18 PMID33831372show ga Many individuals mount nearly identical antibody responses to SARS-CoV-2. To gain insight into how the viral spike (S) protein receptor-binding domain (RBD) might evolve in response to common antibody responses, we studied mutations occurring during virus evolution in a persistently infected immunocompromised individual. We use antibody Fab/RBD structures to predict, and pseudotypes to confirm, that mutations found in late-stage evolved S variants confer resistance to a common class of SARS-CoV-2 neutralizing antibodies we isolated from a healthy COVID-19 convalescent donor. Resistance extends to the polyclonal serum immunoglobulins of four out of four healthy convalescent donors we tested and to monoclonal antibodies in clinical use. We further show that affinity maturation is unimportant for wild-type virus neutralization but is critical to neutralization breadth. Because the mutations we studied foreshadowed emerging variants that are now circulating across the globe, our results have implications to the long-term efficacy of S-directed countermeasures. |*COVID-19/genetics/immunology[MESH] |*Evolution, Molecular[MESH] |*Immunocompromised Host[MESH] |*SARS-CoV-2/genetics/immunology[MESH] |*Spike Glycoprotein, Coronavirus/genetics/immunology[MESH] |Antibodies, Neutralizing[MESH] |Antibodies, Viral/*immunology[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immune Evasion/*immunology[MESH] |Immunoglobulin Fab Fragments/*immunology[MESH] |Male[MESH]SARS-CoV-2 evolution in an immunocompromised host reveals shared neutr(epmc).pdf DeepDyve Pubget Overpricing