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10.1371/journal.ppat.1009453 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009453 33831132!8031418!33831132     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2021 ; 17 (4): e1009453 Nephropedia Template TP {{tp|p=33831132|t=2021. A human coronavirus evolves antigenically to escape antibody immunity |pdf=|usr=}}{{33831132}} gab.com Text A human coronavirus evolves antigenically to escape antibody immunity JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33831132 #FOAvip There is intense interest in antibody immunity to coronaviruses. However, it is unknown if coronaviruses evolve to escape such immunity, and if so, how rapidly. Here we address this question by characterizing the historical evolution of human coronavirus 229E. We identify human sera from the 1980s and 1990s that have neutralizing titers against contemporaneous 229E that are comparable to the anti-SARS-CoV-2 titers induced by SARS-CoV-2 infection or vaccination. We test these sera against 229E strains isolated after sera collection, and find that neutralizing titers are lower against these "future" viruses. In some cases, sera that neutralize contemporaneous 229E viral strains with titers >1:100 do not detectably neutralize strains isolated 8-17 years later. The decreased neutralization of "future" viruses is due to antigenic evolution of the viral spike, especially in the receptor-binding domain. If these results extrapolate to other coronaviruses, then it may be advisable to periodically update SARS-CoV-2 vaccines. Twit Text FOAVip A human coronavirus evolves antigenically to escape antibody immunity ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33831132 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33831132 #FOAvip English Wikipedia <ref>{{Cite pmid|33831132}}</ref> A human coronavirus evolves antigenically to escape antibody immunity #MMPMID33831132 Eguia RT; Crawford KHD; Stevens-Ayers T; Kelnhofer-Millevolte L; Greninger AL; Englund JA; Boeckh MJ; Bloom JD PLoS Pathog 2021[Apr]; 17 (4): e1009453 PMID33831132show ga There is intense interest in antibody immunity to coronaviruses. However, it is unknown if coronaviruses evolve to escape such immunity, and if so, how rapidly. Here we address this question by characterizing the historical evolution of human coronavirus 229E. We identify human sera from the 1980s and 1990s that have neutralizing titers against contemporaneous 229E that are comparable to the anti-SARS-CoV-2 titers induced by SARS-CoV-2 infection or vaccination. We test these sera against 229E strains isolated after sera collection, and find that neutralizing titers are lower against these "future" viruses. In some cases, sera that neutralize contemporaneous 229E viral strains with titers >1:100 do not detectably neutralize strains isolated 8-17 years later. The decreased neutralization of "future" viruses is due to antigenic evolution of the viral spike, especially in the receptor-binding domain. If these results extrapolate to other coronaviruses, then it may be advisable to periodically update SARS-CoV-2 vaccines. |*Immune Evasion[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |Coronavirus 229E, Human/*genetics/*immunology[MESH] |Humans[MESH]A human coronavirus evolves antigenically to escape antibody immunity (epmc).pdf DeepDyve Pubget Overpricing