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10.1111/jth.15339 http://scihub22266oqcxt.onion/10.1111/jth.15339 33830623!8250221!33830623     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33830623&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Thromb+Haemost 2021 ; 19 (7): 1823-1830 Nephropedia Template TP {{tp|p=33830623|t=2021. Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality |pdf=|usr=}}{{33830623}} gab.com Text Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality JO: J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=33830623 #FOAvip BACKGROUND: Coronavirus disease 2019 (COVID-19) is a respiratory disease associated with vascular inflammation and endothelial injury. OBJECTIVES: To correlate circulating angiogenic markers vascular endothelial growth factor A (VEGF-A), placental growth factor (PlGF), and fibroblast growth factor 2 (FGF-2) to in-hospital mortality in COVID-19 adult patients. METHODS: Consecutive ambulatory and hospitalized patients with COVID-19 infection were enrolled. VEGF-A, PlGF, and FGF-2 were measured in each patient </=48 h following admission. RESULTS: The study enrolled 237 patients with suspected COVID-19: 208 patients had a positive diagnostic for COVID-19, of whom 23 were mild outpatients and 185 patients hospitalized after admission. Levels of VEGF-A, PlGF, and FGF-2 significantly increase with the severity of the disease (P < .001). Using a logistic regression model, we found a significant association between the increase of FGF-2 or PlGF and mortality (odds ratio [OR] 1.11, 95% confidence interval [CI; 1.07-1.16], P < .001 for FGF-2 and OR 1.07 95% CI [1.04-1.10], P < .001 for PlGF) while no association were found for VEGF-A levels. Receiver operating characteristic curve analysis was performed and we identified PlGF above 30 pg/ml as the best predictor of in-hospital mortality in COVID-19 patients. Survival analysis for PlGF confirmed its interest for in-hospital mortality prediction, by using a Kaplan-Meier survival curve (P = .001) and a Cox proportional hazard model adjusted to age, body mass index, D-dimer, and C-reactive protein (3.23 95% CI [1.29-8.11], P = .001). CONCLUSION: Angiogenic factor PlGF is a relevant predictive factor for in-hospital mortality in COVID-19 patients. More than a biomarker, we hypothesize that PlGF blocking strategies could be a new interesting therapeutic approach in COVID-19. Twit Text FOAVip Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality ????J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=33830623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33830623 #FOAvip English Wikipedia <ref>{{Cite pmid|33830623}}</ref> Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality #MMPMID33830623 Smadja DM; Philippe A; Bory O; Gendron N; Beauvais A; Gruest M; Peron N; Khider L; Guerin CL; Goudot G; Levavasseur F; Duchemin J; Pene F; Cheurfa C; Szwebel TA; Sourdeau E; Planquette B; Hauw-Berlemont C; Hermann B; Gaussem P; Samama CM; Mirault T; Terrier B; Sanchez O; Rance B; Fontenay M; Diehl JL; Chocron R J Thromb Haemost 2021[Jul]; 19 (7): 1823-1830 PMID33830623show ga BACKGROUND: Coronavirus disease 2019 (COVID-19) is a respiratory disease associated with vascular inflammation and endothelial injury. OBJECTIVES: To correlate circulating angiogenic markers vascular endothelial growth factor A (VEGF-A), placental growth factor (PlGF), and fibroblast growth factor 2 (FGF-2) to in-hospital mortality in COVID-19 adult patients. METHODS: Consecutive ambulatory and hospitalized patients with COVID-19 infection were enrolled. VEGF-A, PlGF, and FGF-2 were measured in each patient |*COVID-19[MESH] |*Vascular Endothelial Growth Factor A[MESH] |Adult[MESH] |Biomarkers[MESH] |Female[MESH] |Hospital Mortality[MESH] |Humans[MESH] |Placenta Growth Factor[MESH]Placental growth factor level in plasma predicts COVID-19 severity and(epmc).pdf DeepDyve Pubget Overpricing