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10.7554/eLife.68808

http://scihub22266oqcxt.onion/10.7554/eLife.68808
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33830018!8064747!33830018
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suck abstract from ncbi


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pmid33830018      Elife 2021 ; 10 (ä): ä
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  • Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection #MMPMID33830018
  • Jones NK; Rivett L; Seaman S; Samworth RJ; Warne B; Workman C; Ferris M; Wright J; Quinnell N; Shaw A; Goodfellow IG; Lehner PJ; Howes R; Wright G; Matheson NJ; Weekes MP
  • Elife 2021[Apr]; 10 (ä): ä PMID33830018show ga
  • The BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) is being utilised internationally for mass COVID-19 vaccination. Evidence of single-dose protection against symptomatic disease has encouraged some countries to opt for delayed booster doses of BNT162b2, but the effect of this strategy on rates of asymptomatic SARS-CoV-2 infection remains unknown. We previously demonstrated frequent pauci- and asymptomatic SARS-CoV-2 infection amongst healthcare workers (HCWs) during the UK's first wave of the COVID-19 pandemic, using a comprehensive PCR-based HCW screening programme (Rivett et al., 2020; Jones et al., 2020). Here, we evaluate the effect of first-dose BNT162b2 vaccination on test positivity rates and find a fourfold reduction in asymptomatic infection amongst HCWs >/=12 days post-vaccination. These data provide real-world evidence of short-term protection against asymptomatic SARS-CoV-2 infection following a single dose of BNT162b2 vaccine, suggesting that mass first-dose vaccination will reduce SARS-CoV-2 transmission, as well as the burden of COVID-19 disease.
  • |Asymptomatic Infections/therapy[MESH]
  • |BNT162 Vaccine[MESH]
  • |COVID-19 Vaccines/administration & dosage/*therapeutic use[MESH]
  • |COVID-19/diagnosis/*prevention & control[MESH]
  • |Health Personnel[MESH]
  • |Humans[MESH]
  • |Immunization Schedule[MESH]
  • |Immunization, Secondary[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]


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