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10.1038/s12276-021-00595-x http://scihub22266oqcxt.onion/10.1038/s12276-021-00595-x 33828231!8024942!33828231     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33828231.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Mol+Med 2021 ; 53 (4): 483-494 Nephropedia Template TP {{tp|p=33828231|t=2021. From bedside to bench: regulation of host factors in SARS-CoV-2 infection |pdf=|usr=}}{{33828231}} gab.com Text From bedside to bench: regulation of host factors in SARS-CoV-2 infection JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33828231 #FOAvip The zoonotic coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), which causes COVID-19 (coronavirus disease-2019), has resulted in a pandemic. This has led to an urgent need to understand the molecular determinants of SARS-CoV-2 infection, factors associated with COVID-19 heterogeneity and severity, and therapeutic options for these patients. In this review, we discuss the role of host factors in SARS-CoV-2 infection and describe variations in host factor expression as mechanisms underlying the symptoms and severity of COVID-19. We focus on two host factors, angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2), implicated in SARS-CoV-2 infection. We also discuss genetic variants associated with COVID-19 severity revealed in selected patients and based on genome-wide association studies (GWASs). Furthermore, we highlight important advances in cell and chromatin biology, such as single-cell RNA and chromatin sequencing and chromosomal conformation assays, as methods that may aid in the discovery of viral-host interactions in COVID-19. Understanding how regulation of host factor genes varies in physiological and pathological states might explain the heterogeneity observed in SARS-CoV-2 infection, help identify pathways for therapeutic development, and identify patients most likely to progress to severe COVID-19. Twit Text FOAVip From bedside to bench: regulation of host factors in SARS-CoV-2 infection ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33828231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33828231 #FOAvip English Wikipedia <ref>{{Cite pmid|33828231}}</ref> From bedside to bench: regulation of host factors in SARS-CoV-2 infection #MMPMID33828231 Ong SYQ; Flyamer IM; Bickmore WA; Biddie SC Exp Mol Med 2021[Apr]; 53 (4): 483-494 PMID33828231show ga The zoonotic coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), which causes COVID-19 (coronavirus disease-2019), has resulted in a pandemic. This has led to an urgent need to understand the molecular determinants of SARS-CoV-2 infection, factors associated with COVID-19 heterogeneity and severity, and therapeutic options for these patients. In this review, we discuss the role of host factors in SARS-CoV-2 infection and describe variations in host factor expression as mechanisms underlying the symptoms and severity of COVID-19. We focus on two host factors, angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2), implicated in SARS-CoV-2 infection. We also discuss genetic variants associated with COVID-19 severity revealed in selected patients and based on genome-wide association studies (GWASs). Furthermore, we highlight important advances in cell and chromatin biology, such as single-cell RNA and chromatin sequencing and chromosomal conformation assays, as methods that may aid in the discovery of viral-host interactions in COVID-19. Understanding how regulation of host factor genes varies in physiological and pathological states might explain the heterogeneity observed in SARS-CoV-2 infection, help identify pathways for therapeutic development, and identify patients most likely to progress to severe COVID-19. |Angiotensin-Converting Enzyme 2/*genetics/metabolism[MESH] |COVID-19/etiology/*genetics[MESH] |Gene Expression[MESH] |Genetic Variation[MESH] |Host-Pathogen Interactions/*physiology[MESH] |Humans[MESH] |Interferon Type I/genetics/metabolism[MESH] |Lung/pathology/virology[MESH]From bedside to bench: regulation of host factors in SARS-CoV-2 infect(epmc).pdf DeepDyve Pubget Overpricing