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10.1038/s41598-021-87289-6

http://scihub22266oqcxt.onion/10.1038/s41598-021-87289-6
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33828214!8027209!33828214
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suck abstract from ncbi


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pmid33828214      Sci+Rep 2021 ; 11 (1): 7614
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  • Evaluation of 11 SARS-CoV-2 antibody tests by using samples from patients with defined IgG antibody titers #MMPMID33828214
  • Lagerqvist N; Maleki KT; Verner-Carlsson J; Olausson M; Dillner J; Wigren Bystrom J; Monsen T; Forsell M; Eriksson J; Bogdanovic G; Muschiol S; Ljunggren J; Repo J; Kjerstadius T; Muradrasoli S; Brytting M; Szekely Bjorndal A; Akerlund T; Nilsson C; Klingstrom J
  • Sci Rep 2021[Apr]; 11 (1): 7614 PMID33828214show ga
  • We evaluated the performance of 11 SARS-CoV-2 antibody tests using a reference set of heat-inactivated samples from 278 unexposed persons and 258 COVID-19 patients, some of whom contributed serial samples. The reference set included samples with a variation in SARS-CoV-2 IgG antibody titers, as determined by an in-house immunofluorescence assay (IFA). The five evaluated rapid diagnostic tests had a specificity of 99.0% and a sensitivity that ranged from 56.3 to 81.6% and decreased with low IFA IgG titers. The specificity was > 99% for five out of six platform-based tests, and when assessed using samples collected >/= 22 days after symptom onset, two assays had a sensitivity of > 96%. These two assays also detected samples with low IFA titers more frequently than the other assays. In conclusion, the evaluated antibody tests showed a heterogeneity in their performances and only a few tests performed well with samples having low IFA IgG titers, an important aspect for diagnostics and epidemiological investigations.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Viral/blood/immunology[MESH]
  • |COVID-19 Serological Testing/economics/*methods[MESH]
  • |COVID-19/blood/*diagnosis/immunology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/blood/immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/immunology/*isolation & purification[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Time Factors[MESH]


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