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10.1080/22221751.2021.1913974 http://scihub22266oqcxt.onion/10.1080/22221751.2021.1913974 33825619!8812745!33825619     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2021 ; 10 (1): 797-809 Nephropedia Template TP {{tp|p=33825619|t=2021. Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster |pdf=|usr=}}{{33825619}} gab.com Text Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33825619 #FOAvip Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question of immunity generated by a single infection is sufficient to provide sterilizing/protective immunity to a subsequent SARS-CoV-2 re-exposure. The Golden Syrian hamster is a manageable animal model to explore immunological mechanisms able to counteract COVID-19, as it recapitulates pathological aspects of mild to moderately affected patients. Here, we report that SARS-CoV-2-inoculated hamsters resolve infection in the upper and lower respiratory tracts within seven days upon inoculation with the Cat01 (G614) SARS-CoV-2 isolate. Three weeks after the primary challenge, and despite high titres of neutralizing antibodies, half of the animals were susceptible to reinfection by both identical (Cat01, G614) and variant (WA/1, D614) SARS-CoV-2 isolates. However, upon re-inoculation, only nasal tissues were transiently infected with much lower viral replication than those observed after the first inoculation. These data indicate that a primary SARS-CoV-2 infection is not sufficient to elicit a sterilizing immunity in hamster models but protects against lung disease. Twit Text FOAVip Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33825619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33825619 #FOAvip English Wikipedia <ref>{{Cite pmid|33825619}}</ref> Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster #MMPMID33825619 Brustolin M; Rodon J; Rodriguez de la Concepcion ML; Avila-Nieto C; Cantero G; Perez M; Te N; Noguera-Julian M; Guallar V; Valencia A; Roca N; Izquierdo-Useros N; Blanco J; Clotet B; Bensaid A; Carrillo J; Vergara-Alert J; Segales J Emerg Microbes Infect 2021[Dec]; 10 (1): 797-809 PMID33825619show ga Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question of immunity generated by a single infection is sufficient to provide sterilizing/protective immunity to a subsequent SARS-CoV-2 re-exposure. The Golden Syrian hamster is a manageable animal model to explore immunological mechanisms able to counteract COVID-19, as it recapitulates pathological aspects of mild to moderately affected patients. Here, we report that SARS-CoV-2-inoculated hamsters resolve infection in the upper and lower respiratory tracts within seven days upon inoculation with the Cat01 (G614) SARS-CoV-2 isolate. Three weeks after the primary challenge, and despite high titres of neutralizing antibodies, half of the animals were susceptible to reinfection by both identical (Cat01, G614) and variant (WA/1, D614) SARS-CoV-2 isolates. However, upon re-inoculation, only nasal tissues were transiently infected with much lower viral replication than those observed after the first inoculation. These data indicate that a primary SARS-CoV-2 infection is not sufficient to elicit a sterilizing immunity in hamster models but protects against lung disease. |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19/diagnosis/*immunology/pathology/*virology[MESH] |Cell Line[MESH] |Cricetinae[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Host-Pathogen Interactions/*immunology[MESH] |Humans[MESH] |Immunity, Humoral[MESH] |Immunohistochemistry[MESH] |Male[MESH] |Neutralization Tests[MESH] |Reinfection/*virology[MESH] |SARS-CoV-2/genetics/*immunology/*isolation & purification[MESH] |Viral Load[MESH]Protection against reinfection with D614- or G614-SARS-CoV-2 isolates (epmc).pdf DeepDyve Pubget Overpricing