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10.1007/s15010-021-01606-9

http://scihub22266oqcxt.onion/10.1007/s15010-021-01606-9
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suck abstract from ncbi


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pmid33825125      Infection 2021 ; 49 (4): 757-762
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  • CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity #MMPMID33825125
  • Doehn JM; Tabeling C; Biesen R; Saccomanno J; Madlung E; Pappe E; Gabriel F; Kurth F; Meisel C; Corman VM; Hanitsch LG; Treskatsch S; Heim K; Stegemann MS; Ruwwe-Glosenkamp C; Muller-Redetzky HC; Uhrig A; Somasundaram R; Spies C; von Bernuth H; Hofmann J; Drosten C; Suttorp N; Witzenrath M; Sander LE; Hubner RH
  • Infection 2021[Aug]; 49 (4): 757-762 PMID33825125show ga
  • Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I interferons are important in the defense of viral infections. Recently, neutralizing IgG auto-antibodies against type I interferons were found in patients with severe COVID-19 infection. Here, we analyzed expression of CD169/SIGLEC1, a well described downstream molecule in interferon signaling, and found increased monocytic CD169/SIGLEC1 expression levels in patients with mild, acute COVID-19, compared to patients with severe disease. We recommend further clinical studies to evaluate the value of CD169/SIGLEC1 expression in patients with COVID-19 with or without auto-antibodies against type I interferons.
  • |Aged[MESH]
  • |COVID-19/*immunology[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Longitudinal Studies[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Monocytes/*immunology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*physiology[MESH]
  • |Severity of Illness Index[MESH]
  • |Sialic Acid Binding Ig-like Lectin 1/biosynthesis/*blood[MESH]


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