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10.2147/RMHP.S282962 http://scihub22266oqcxt.onion/10.2147/RMHP.S282962 33824608!8018360!33824608     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Risk+Manag+Healthc+Policy 2021 ; 14 (ä): 1311-1317 Nephropedia Template TP {{tp|p=33824608|t=2021. Cycle Threshold Values in the Context of Multiple RT-PCR Testing for SARS-CoV-2 |pdf=|usr=}}{{33824608}} gab.com Text Cycle Threshold Values in the Context of Multiple RT-PCR Testing for SARS-CoV-2 JO: Risk Manag Healthc Policy http://www.kidney.de/pget.php?&tw=1&pmid=33824608 #FOAvip PURPOSE: Discharge or follow up of confirmed coronavirus disease 2019 (COVID-19) cases depend on accurate interpretation of RT-PCR. Currently, positive/negative interpretations are based on amplification instead of quantification of cycle threshold (Ct) values, which could be used as proxies of patient infectiousness. Here, we measured Ct values in hospitalized confirmed COVID-19 patients at different times and its implications in diagnosis and follow up. PATIENTS AND METHODS: Observational study between March 17th-May 12th, 2020 using multiple RT-PCR testing. A cohort of 118 Hispanic hospitalized patients with confirmed COVID-19 diagnosis in a reference hospital in Quito, Ecuador. Multiple RT-PCR tests were performed using deep nasal swab samples and the assessment of SARS-CoV-2 genes N, RdRP, and E. RESULTS: Patients' median age was of 49 years (range: 24-91) with a male majority (62.7%). We found increasing levels of Ct values in time, with a mean Ct value of 29.13 (n = 61, standard deviation (sd) = 5.55) for the first test and 34.38 (n = 60, sd = 4), 35.52 (n = 20, sd = 2.85), and 36.12 (n = 6, sd = 3.28), for the second, third, and fourth tests, respectively. Time to RT-PCR lack of amplification for all tests was of 34 days while time to RT-PCR Ct values >33 was of 30 days. CONCLUSION: Cycle thresholds can potentially be used to improve diagnosis, management and control. We found that turnover time for negativity can be large for hospitalized patients and that 11% cases persisted with infectious Ct values for more time than the current isolation recommendations. Twit Text FOAVip Cycle Threshold Values in the Context of Multiple RT-PCR Testing for SARS-CoV-2 ????Risk Manag Healthc Policy http://www.kidney.de/pget.php?&tw=1&pmid=33824608 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33824608 #FOAvip English Wikipedia <ref>{{Cite pmid|33824608}}</ref> Cycle Threshold Values in the Context of Multiple RT-PCR Testing for SARS-CoV-2 #MMPMID33824608 Romero-Alvarez D; Garzon-Chavez D; Espinosa F; Ligna E; Teran E; Mora F; Espin E; Alban C; Galarza JM; Reyes J Risk Manag Healthc Policy 2021[]; 14 (ä): 1311-1317 PMID33824608show ga PURPOSE: Discharge or follow up of confirmed coronavirus disease 2019 (COVID-19) cases depend on accurate interpretation of RT-PCR. Currently, positive/negative interpretations are based on amplification instead of quantification of cycle threshold (Ct) values, which could be used as proxies of patient infectiousness. Here, we measured Ct values in hospitalized confirmed COVID-19 patients at different times and its implications in diagnosis and follow up. PATIENTS AND METHODS: Observational study between March 17th-May 12th, 2020 using multiple RT-PCR testing. A cohort of 118 Hispanic hospitalized patients with confirmed COVID-19 diagnosis in a reference hospital in Quito, Ecuador. Multiple RT-PCR tests were performed using deep nasal swab samples and the assessment of SARS-CoV-2 genes N, RdRP, and E. RESULTS: Patients' median age was of 49 years (range: 24-91) with a male majority (62.7%). We found increasing levels of Ct values in time, with a mean Ct value of 29.13 (n = 61, standard deviation (sd) = 5.55) for the first test and 34.38 (n = 60, sd = 4), 35.52 (n = 20, sd = 2.85), and 36.12 (n = 6, sd = 3.28), for the second, third, and fourth tests, respectively. Time to RT-PCR lack of amplification for all tests was of 34 days while time to RT-PCR Ct values >33 was of 30 days. CONCLUSION: Cycle thresholds can potentially be used to improve diagnosis, management and control. We found that turnover time for negativity can be large for hospitalized patients and that 11% cases persisted with infectious Ct values for more time than the current isolation recommendations. äCycle Threshold Values in the Context of Multiple RT-PCR Testing for S(epmc).pdf DeepDyve Pubget Overpricing