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10.1016/j.mehy.2021.110564

http://scihub22266oqcxt.onion/10.1016/j.mehy.2021.110564
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33823371!7985609!33823371
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suck abstract from ncbi


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pmid33823371      Med+Hypotheses 2021 ; 150 (ä): 110564
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  • Endotheliitis, endothelin, and endothelin receptor blockers in COVID-19 #MMPMID33823371
  • Sanghavi DK; Titus A; Caulfield TR; David Freeman W
  • Med Hypotheses 2021[May]; 150 (ä): 110564 PMID33823371show ga
  • We summarize the role of endothelin as a potent vasoconstrictor, pro-inflammatory, pro-oxidative agent in the pathophysiologic effects and end-organ dysfunction of coronavirus disease 2019 (COVID-19). Endotheliitis is an under-recognized pathophysiologic process that causes various types of dysfunction in end organs, including heart, lung, kidney, and brain. Endothelin receptor blockers, such as bosentan and sitaxentan, can pave a path ahead in the realm of COVID-19 therapies. These agents have a potential role against COVID-19 and should be studied in research trials to determine their efficacy in treatment of this severe disease.
  • |*COVID-19 Drug Treatment[MESH]
  • |Endothelin Receptor Antagonists/*therapeutic use[MESH]
  • |Endothelins[MESH]
  • |Endothelium, Vascular/*pathology[MESH]
  • |Humans[MESH]
  • |Receptors, Endothelin[MESH]


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