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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Med+Hypotheses 2021 ; 150 (ä): 110564 Nephropedia Template TP
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Endotheliitis, endothelin, and endothelin receptor blockers in COVID-19 #MMPMID33823371
Sanghavi DK; Titus A; Caulfield TR; David Freeman W
Med Hypotheses 2021[May]; 150 (ä): 110564 PMID33823371show ga
We summarize the role of endothelin as a potent vasoconstrictor, pro-inflammatory, pro-oxidative agent in the pathophysiologic effects and end-organ dysfunction of coronavirus disease 2019 (COVID-19). Endotheliitis is an under-recognized pathophysiologic process that causes various types of dysfunction in end organs, including heart, lung, kidney, and brain. Endothelin receptor blockers, such as bosentan and sitaxentan, can pave a path ahead in the realm of COVID-19 therapies. These agents have a potential role against COVID-19 and should be studied in research trials to determine their efficacy in treatment of this severe disease.