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10.1615/IntJMedMushrooms.2021037942

http://scihub22266oqcxt.onion/10.1615/IntJMedMushrooms.2021037942
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33822495!ä!33822495

suck abstract from ncbi


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pmid33822495      Int+J+Med+Mushrooms 2021 ; 23 (3): 1-14
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  • Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Terpenoids May Interfere with SARS-CoV-2 Spike Protein Recognition of the Host Cell: A Molecular Docking Study #MMPMID33822495
  • Basal WT; Elfiky A; Eid J
  • Int J Med Mushrooms 2021[]; 23 (3): 1-14 PMID33822495show ga
  • The most challenging threat facing the global community today is the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite global efforts to develop suitable treatments, very few specific antiviral agents have been suggested and the virus remains a serious global health risk. In vivo animal experiments have demonstrated that bioactive mycochemical constituents of Inonotus obliquus have immunomodulatory, antimicrobial, and antiviral properties. The present study investigates the antiviral potential of I. obliquus terpenoids against COVID-19 using a molecular docking study. The in silico study elucidates the ability of most of the terpenoid components to interact with the receptor-binding domain of SARS-CoV-2 spike glycoprotein with excellent affinity. Additionally, we found that both betulinic acid and inonotusane C could bind and stably interact with the spike protein near the host cell recognition site of angiotensin-converting enzyme 2.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Molecular Docking Simulation[MESH]
  • |Inhibitory Concentration 50[MESH]
  • |Inonotus/*chemistry[MESH]
  • |Molecular Structure[MESH]
  • |SARS-CoV-2/*drug effects[MESH]
  • |Spike Glycoprotein, Coronavirus/*drug effects/metabolism[MESH]


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