Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/2211-5463.13153 http://scihub22266oqcxt.onion/10.1002/2211-5463.13153 33822489!8091584!33822489     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Open+Bio 2021 ; 11 (5): 1452-1464 Nephropedia Template TP {{tp|p=33822489|t=2021. iPSC screening for drug repurposing identifies anti-RNA virus agents modulating host cell susceptibility |pdf=|usr=}}{{33822489}} gab.com Text iPSC screening for drug repurposing identifies anti-RNA virus agents modulating host cell susceptibility JO: FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=33822489 #FOAvip Human pathogenic RNA viruses are threats to public health because they are prone to escaping the human immune system through mutations of genomic RNA, thereby causing local outbreaks and global pandemics of emerging or re-emerging viral diseases. While specific therapeutics and vaccines are being developed, a broad-spectrum therapeutic agent for RNA viruses would be beneficial for targeting newly emerging and mutated RNA viruses. In this study, we conducted a screen of repurposed drugs using Sendai virus (an RNA virus of the family Paramyxoviridae), with human-induced pluripotent stem cells (iPSCs) to explore existing drugs that may present anti-RNA viral activity. Selected hit compounds were evaluated for their efficacy against two important human pathogens: Ebola virus (EBOV) using Huh7 cells and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using Vero E6 cells. Selective estrogen receptor modulators (SERMs), including raloxifene, exhibited antiviral activities against EBOV and SARS-CoV-2. Pioglitazone, a PPARgamma agonist, also exhibited antiviral activities against SARS-CoV-2, and both raloxifene and pioglitazone presented a synergistic antiviral effect. Finally, we demonstrated that SERMs blocked entry steps of SARS-CoV-2 into host cells. These findings suggest that the identified FDA-approved drugs can modulate host cell susceptibility against RNA viruses. Twit Text FOAVip iPSC screening for drug repurposing identifies anti-RNA virus agents modulating host cell susceptibility ????FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=33822489 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33822489 #FOAvip English Wikipedia <ref>{{Cite pmid|33822489}}</ref> iPSC screening for drug repurposing identifies anti-RNA virus agents modulating host cell susceptibility #MMPMID33822489 Imamura K; Sakurai Y; Enami T; Shibukawa R; Nishi Y; Ohta A; Shu T; Kawaguchi J; Okada S; Hoenen T; Yasuda J; Inoue H FEBS Open Bio 2021[May]; 11 (5): 1452-1464 PMID33822489show ga Human pathogenic RNA viruses are threats to public health because they are prone to escaping the human immune system through mutations of genomic RNA, thereby causing local outbreaks and global pandemics of emerging or re-emerging viral diseases. While specific therapeutics and vaccines are being developed, a broad-spectrum therapeutic agent for RNA viruses would be beneficial for targeting newly emerging and mutated RNA viruses. In this study, we conducted a screen of repurposed drugs using Sendai virus (an RNA virus of the family Paramyxoviridae), with human-induced pluripotent stem cells (iPSCs) to explore existing drugs that may present anti-RNA viral activity. Selected hit compounds were evaluated for their efficacy against two important human pathogens: Ebola virus (EBOV) using Huh7 cells and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using Vero E6 cells. Selective estrogen receptor modulators (SERMs), including raloxifene, exhibited antiviral activities against EBOV and SARS-CoV-2. Pioglitazone, a PPARgamma agonist, also exhibited antiviral activities against SARS-CoV-2, and both raloxifene and pioglitazone presented a synergistic antiviral effect. Finally, we demonstrated that SERMs blocked entry steps of SARS-CoV-2 into host cells. These findings suggest that the identified FDA-approved drugs can modulate host cell susceptibility against RNA viruses. |*Drug Repositioning/methods[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19 Drug Treatment[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Ebolavirus/drug effects/physiology[MESH] |Humans[MESH] |Induced Pluripotent Stem Cells/virology[MESH] |Microbial Sensitivity Tests/methods[MESH] |Pioglitazone/pharmacology[MESH] |RNA Viruses/*drug effects/physiology[MESH] |RNA, Viral/*antagonists & inhibitors[MESH] |Raloxifene Hydrochloride/pharmacology[MESH] |SARS-CoV-2/*drug effects/physiology[MESH] |Selective Estrogen Receptor Modulators/pharmacology[MESH] |Sendai virus/drug effects/physiology[MESH]iPSC screening for drug repurposing identifies anti-RNA virus agents m(epmc).pdf DeepDyve Pubget Overpricing