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10.1093/infdis/jiab176

http://scihub22266oqcxt.onion/10.1093/infdis/jiab176
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33822097!8083569!33822097
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suck abstract from ncbi


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pmid33822097      J+Infect+Dis 2021 ; 224 (1): 70-80
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  • Differential T-Cell Reactivity to Endemic Coronaviruses and SARS-CoV-2 in Community and Health Care Workers #MMPMID33822097
  • da Silva Antunes R; Pallikkuth S; Williams E; Dawen Yu E; Mateus J; Quiambao L; Wang E; Rawlings SA; Stadlbauer D; Jiang K; Amanat F; Arnold D; Andrews D; Fuego I; Dan JM; Grifoni A; Weiskopf D; Krammer F; Crotty S; Hoffer ME; Pahwa SG; Sette A
  • J Infect Dis 2021[Jul]; 224 (1): 70-80 PMID33822097show ga
  • Herein we measured CD4+ T-cell responses against common cold coronaviruses (CCC) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in high-risk health care workers (HCW) and community controls. We observed higher levels of CCC-reactive T cells in SARS-CoV-2-seronegative HCW compared to community donors, consistent with potential higher occupational exposure of HCW to CCC. We further show that SARS-CoV-2 T-cell reactivity of seronegative HCW was higher than community controls and correlation between CCC and SARS-CoV-2 responses is consistent with cross-reactivity and not associated with recent in vivo activation. Surprisingly, CCC T-cell reactivity was decreased in SARS-CoV-2-infected HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses, either directly or indirectly. This result was unexpected, but consistently detected in independent cohorts derived from Miami and San Diego. CD4+ T-cell responses against common cold coronaviruses (CCC) are elevated in SARS-CoV-2 seronegative high-risk health care workers (HCW) compared to COVID-19 convalescent HCW, suggesting that exposure to SARS-CoV-2 might interfere with CCC responses and/or cross-reactivity associated with a protective effect.
  • |*Health Personnel[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral[MESH]
  • |Biomarkers[MESH]
  • |CD4-Positive T-Lymphocytes/immunology/metabolism[MESH]
  • |CD8-Positive T-Lymphocytes/immunology/metabolism[MESH]
  • |COVID-19/diagnosis/*epidemiology/*immunology/virology[MESH]
  • |Enzyme-Linked Immunosorbent Assay[MESH]
  • |Epitopes, T-Lymphocyte/chemistry/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunophenotyping[MESH]
  • |Lymphocyte Activation/immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Peptides/chemistry/immunology[MESH]
  • |Public Health Surveillance[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Seroepidemiologic Studies[MESH]
  • |Severity of Illness Index[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]


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