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10.1002/eahr.500089 http://scihub22266oqcxt.onion/10.1002/eahr.500089 33821569!8251187!33821569     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ethics+Hum+Res 2021 ; 43 (3): 37-41 Nephropedia Template TP {{tp|p=33821569|t=2021. SARS-CoV-2 Human Challenge Trials: Rethinking the Recruitment of Healthy Young Adults First |pdf=|usr=}}{{33821569}} gab.com Text SARS-CoV-2 Human Challenge Trials: Rethinking the Recruitment of Healthy Young Adults First JO: Ethics Hum Res http://www.kidney.de/pget.php?&tw=1&pmid=33821569 #FOAvip In the midst of the ongoing Covid-19 pandemic, researchers across the globe are still working to develop effective vaccines. To expedite this process even further, human challenge trials have been proposed by the World Health Organization (WHO) as an alternative to conventional approaches. In such trials, healthy volunteers are deliberately infected with the pathogen of interest, enabling scientists to study the infection process and facilitate further research on treatments or prophylactics, including vaccines. While human challenge trials would offer a collective benefit to society, minimizing the risks is always difficult. Ethical controversy thus inevitably surrounds these trials. Typically, healthy young adults are recruited to serve as the first candidate subjects for human challenge trials because they are generally considered to represent a low-risk population. Here, we present three reasons for doubt about this healthy-young-adults-first criterion and give justification for also recruiting healthy older adults (or not-young adults), meaning those over 30 years of age, to participate in such trials for SARS-CoV-2. Twit Text FOAVip SARS-CoV-2 Human Challenge Trials: Rethinking the Recruitment of Healthy Young Adults First ????Ethics Hum Res http://www.kidney.de/pget.php?&tw=1&pmid=33821569 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33821569 #FOAvip English Wikipedia <ref>{{Cite pmid|33821569}}</ref> SARS-CoV-2 Human Challenge Trials: Rethinking the Recruitment of Healthy Young Adults First #MMPMID33821569 Matsui K; Inoue Y; Yamamoto K Ethics Hum Res 2021[May]; 43 (3): 37-41 PMID33821569show ga In the midst of the ongoing Covid-19 pandemic, researchers across the globe are still working to develop effective vaccines. To expedite this process even further, human challenge trials have been proposed by the World Health Organization (WHO) as an alternative to conventional approaches. In such trials, healthy volunteers are deliberately infected with the pathogen of interest, enabling scientists to study the infection process and facilitate further research on treatments or prophylactics, including vaccines. While human challenge trials would offer a collective benefit to society, minimizing the risks is always difficult. Ethical controversy thus inevitably surrounds these trials. Typically, healthy young adults are recruited to serve as the first candidate subjects for human challenge trials because they are generally considered to represent a low-risk population. Here, we present three reasons for doubt about this healthy-young-adults-first criterion and give justification for also recruiting healthy older adults (or not-young adults), meaning those over 30 years of age, to participate in such trials for SARS-CoV-2. |Adult[MESH] |Age Factors[MESH] |Antiviral Agents/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19 Vaccines/therapeutic use[MESH] |COVID-19/mortality/prevention & control/*therapy[MESH] |Clinical Trials as Topic/*ethics/methods[MESH] |Humans[MESH] |Patient Selection/*ethics[MESH] |SARS-CoV-2[MESH]SARS-CoV-2 Human Challenge Trials: Rethinking the Recruitment of Healt(epmc).pdf DeepDyve Pubget Overpricing