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10.1002/mco2.60

http://scihub22266oqcxt.onion/10.1002/mco2.60
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33821254!8013425!33821254
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suck abstract from ncbi


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pmid33821254      MedComm+(2020) 2021 ; 2 (1): 101-113
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  • A potent neutralizing nanobody against SARS-CoV-2 with inhaled delivery potential #MMPMID33821254
  • Gai J; Ma L; Li G; Zhu M; Qiao P; Li X; Zhang H; Zhang Y; Chen Y; Ji W; Zhang H; Cao H; Li X; Gong R; Wan Y
  • MedComm (2020) 2021[Mar]; 2 (1): 101-113 PMID33821254show ga
  • The coronavirus disease 2019 (COVID-19) pandemic has become a serious burden on global public health. Although therapeutic drugs against COVID-19 have been used in many countries, their efficacy is still limited. We here reported nanobody (Nb) phage display libraries derived from four camels immunized with the SARS-CoV-2 spike receptor-binding domain (RBD), from which 381 Nbs were identified to recognize SARS-CoV-2-RBD. Furthermore, seven Nbs were shown to block interaction of human angiotensin-converting enzyme 2 (ACE2) with SARS-CoV-2-RBD variants and two Nbs blocked the interaction of human ACE2 with bat-SL-CoV-WIV1-RBD and SARS-CoV-1-RBD. Among these candidates, Nb11-59 exhibited the highest activity against authentic SARS-CoV-2 with 50% neutralizing dose (ND(50)) of 0.55 mug/ml. Nb11-59 can be produced on large scale in Pichia pastoris, with 20 g/L titer and 99.36% purity. It also showed good stability profile, and nebulization did not impact its stability. Overall, Nb11-59 might be a promising prophylactic and therapeutic molecule against COVID-19, especially through inhalation delivery.
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