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10.1016/j.medj.2021.03.013 http://scihub22266oqcxt.onion/10.1016/j.medj.2021.03.013 33821250!8011689!33821250     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med 2021 ; 2 (6): 720-735.e4 Nephropedia Template TP {{tp|p=33821250|t=2021. Alterations in T and B cell function persist in convalescent COVID-19 patients |pdf=|usr=}}{{33821250}} gab.com Text Alterations in T and B cell function persist in convalescent COVID-19 patients JO: Med http://www.kidney.de/pget.php?&tw=1&pmid=33821250 #FOAvip BACKGROUND: Emerging studies indicate that some coronavirus disease 2019 (COVID-19) patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however, the long-term immune response in these patients presently remains ill-defined. METHODS: Here, we describe the phenotypic and functional characteristics of B and T cells in hospitalized COVID-19 patients during acute disease and at 3-6 months of convalescence. FINDINGS: We report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed continued alterations with persistence of a cytotoxic program evident in CD8(+) T cells as well as elevated production of type 1 cytokines and interleukin-17 (IL-17). Interestingly, B cells from patients with acute COVID-19 displayed an IL-6/IL-10 cytokine imbalance in response to Toll-like receptor activation, skewed toward a pro-inflammatory phenotype. Whereas the frequency of IL-6(+) B cells was restored in convalescent patients irrespective of clinical outcome, the recovery of IL-10(+) B cells was associated with the resolution of lung pathology. CONCLUSIONS: Our data detail lymphocyte alterations in previously hospitalized COVID-19 patients up to 6 months following hospital discharge and identify 3 subgroups of convalescent patients based on distinct lymphocyte phenotypes, with 1 subgroup associated with poorer clinical outcome. We propose that alterations in B and T cell function following hospitalization with COVID-19 could affect longer-term immunity and contribute to some persistent symptoms observed in convalescent COVID-19 patients. FUNDING: Provided by UKRI, Lister Institute of Preventative Medicine, the Wellcome Trust, The Kennedy Trust for Rheumatology Research, and 3M Global Giving. Twit Text FOAVip Alterations in T and B cell function persist in convalescent COVID-19 patients ????Med http://www.kidney.de/pget.php?&tw=1&pmid=33821250 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33821250 #FOAvip English Wikipedia <ref>{{Cite pmid|33821250}}</ref> Alterations in T and B cell function persist in convalescent COVID-19 patients #MMPMID33821250 Shuwa HA; Shaw TN; Knight SB; Wemyss K; McClure FA; Pearmain L; Prise I; Jagger C; Morgan DJ; Khan S; Brand O; Mann ER; Ustianowski A; Bakerly ND; Dark P; Brightling CE; Brij S; Felton T; Simpson A; Grainger JR; Hussell T; Konkel JE; Menon M Med 2021[Jun]; 2 (6): 720-735.e4 PMID33821250show ga BACKGROUND: Emerging studies indicate that some coronavirus disease 2019 (COVID-19) patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however, the long-term immune response in these patients presently remains ill-defined. METHODS: Here, we describe the phenotypic and functional characteristics of B and T cells in hospitalized COVID-19 patients during acute disease and at 3-6 months of convalescence. FINDINGS: We report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed continued alterations with persistence of a cytotoxic program evident in CD8(+) T cells as well as elevated production of type 1 cytokines and interleukin-17 (IL-17). Interestingly, B cells from patients with acute COVID-19 displayed an IL-6/IL-10 cytokine imbalance in response to Toll-like receptor activation, skewed toward a pro-inflammatory phenotype. Whereas the frequency of IL-6(+) B cells was restored in convalescent patients irrespective of clinical outcome, the recovery of IL-10(+) B cells was associated with the resolution of lung pathology. CONCLUSIONS: Our data detail lymphocyte alterations in previously hospitalized COVID-19 patients up to 6 months following hospital discharge and identify 3 subgroups of convalescent patients based on distinct lymphocyte phenotypes, with 1 subgroup associated with poorer clinical outcome. We propose that alterations in B and T cell function following hospitalization with COVID-19 could affect longer-term immunity and contribute to some persistent symptoms observed in convalescent COVID-19 patients. FUNDING: Provided by UKRI, Lister Institute of Preventative Medicine, the Wellcome Trust, The Kennedy Trust for Rheumatology Research, and 3M Global Giving. |*COVID-19[MESH] |CD8-Positive T-Lymphocytes[MESH] |Cytokines[MESH] |Humans[MESH] |Interleukin-10[MESH] |Interleukin-6[MESH]Alterations in T and B cell function persist in convalescent COVID-19 (epmc).pdf DeepDyve Pubget Overpricing