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10.1016/j.resinv.2021.02.008

http://scihub22266oqcxt.onion/10.1016/j.resinv.2021.02.008
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33820751!7972804!33820751
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suck abstract from ncbi


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pmid33820751      Respir+Investig 2021 ; 59 (4): 436-445
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  • Chest CT severity score and radiological patterns as predictors of disease severity, ICU admission, and viral positivity in COVID-19 patients #MMPMID33820751
  • Bellos I; Tavernaraki K; Stefanidis K; Michalopoulou O; Lourida G; Korompoki E; Thanou I; Thanos L; Pefanis A; Argyraki A
  • Respir Investig 2021[Jul]; 59 (4): 436-445 PMID33820751show ga
  • BACKGROUND: Chest computed tomography (CT) is a useful tool for the diagnosis of coronavirus disease-2019 (COVID-19), although its exact value for predicting critical illness remains unclear. This study evaluated the efficacy of chest CT to predict disease progression, pulmonary complications, and viral positivity duration. METHODS: A single-center cohort study was conducted by consecutively including hospitalized patients with confirmed COVID-19. The chest CT patterns were described and a total severity score was calculated. The predictive accuracy of the severity score was evaluated using the receiver operating characteristic analysis, while a Cox proportional hazards regression model was implemented to identify the radiological features that are linked to prolonged duration of viral positivity. RESULTS: Overall, 42 patients were included with 10 of them requiring intensive care unit admission. The most common lesions were ground glass opacities (92.9%), consolidation (66.7%), and crazy-paving patterns (61.9%). The total severity score significantly correlated with inflammatory and respiratory distress markers, as well as with admission CURB-65 and PSI/PORT scores. It was estimated to predict critical illness with a sensitivity and specificity of 75% and 70%, respectively. Time-to-event analysis indicated that patients without ground-glass opacities presented significantly shorter median viral positivity (16 vs. 27 days). CONCLUSIONS: Chest CT severity score positively correlates with markers of COVID-19 severity and presents promising efficacy in predicting critical illness. It is suggested that ground-glass opacities are linked to prolonged viral positivity. Further studies should confirm the efficacy of the severity score and elucidate the long-term pulmonary effects of COVID-19.
  • |*Critical Illness[MESH]
  • |*Diagnostic Tests, Routine[MESH]
  • |*Intensive Care Units[MESH]
  • |*Radiography, Thoracic[MESH]
  • |*Tomography, X-Ray Computed[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19 Testing/methods[MESH]
  • |COVID-19/*diagnostic imaging/*virology[MESH]
  • |Cohort Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Predictive Value of Tests[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Sensitivity and Specificity[MESH]


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