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10.2174/0929867328666210405113253

http://scihub22266oqcxt.onion/10.2174/0929867328666210405113253
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33820514!ä!33820514

suck abstract from ncbi


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pmid33820514      Curr+Med+Chem 2021 ; 28 (34): 7157-7184
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  • The Main Receptors Involved in the COVID-19: A Systematic Review and Meta-Analysis #MMPMID33820514
  • Camara AB; Brandao IA
  • Curr Med Chem 2021[Oct]; 28 (34): 7157-7184 PMID33820514show ga
  • OBJECTIVE: This review aims to study the receptor's family and functions most related to COVID-19 infection and also suggest the tissue and cell location on which the majority of COVID-19 receptors are mainly expressed. METHODS: This systematic review is according to PRISMA guidelines. PubMed, Cochrane, SciELO, Lilacs, Web of Science, and DOAJ databases were used. Clinical trials and research articles studying receptors related to COVID-19 were included in this review. R programming language was used to elaborate charts and receptors network, and SPSS(26v) software was used to perform statistical analysis (PROSPERO: CRD42020210643). RESULTS: The majority of studies on the involvement of receptors in COVID-19 included plasma receptors and G protein-coupled receptor families (p<0.05). These receptors are highly expressed in the brain (24%) and 80% of them can interact with each other in a protein network, exerting some regulatory effects on various tissues. The main influential receptor in the network of receptors involved in the COVID-19 was the EGFR and the majority of receptors were associated with pathological processes of the disease (p<0.05), including the amplification of inflammatory responses in COVID-19, which may be related to neurological disorders in some cases. Studies on receptors involved in the COVID-19 included mainly patients from the United States, Spain, and Brazil (p<0.05). CONCLUSION: Plasma receptors and G protein-coupled receptors, especially the EGFR, involved in pathological effects of the COVID-19 inflammatory process in the brain have shown significant importance in this review.
  • |*COVID-19[MESH]
  • |*Nervous System Diseases/virology[MESH]
  • |*Receptors, G-Protein-Coupled[MESH]
  • |*Receptors, Virus[MESH]
  • |Brain[MESH]


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