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10.4269/ajtmh.21-0034

http://scihub22266oqcxt.onion/10.4269/ajtmh.21-0034
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33819170!8176471!33819170
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suck abstract from ncbi


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pmid33819170      Am+J+Trop+Med+Hyg 2021 ; 104 (6): 2190-2194
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  • Enhanced IL-6 and IL-12B Gene Expression After SARS-CoV-2 Infection in Leprosy Patients May Increase the Risk of Neural Damage #MMPMID33819170
  • Santos Morais Junior G; Shu Kurizky P; Penha Silva Cerqueira SR; Holanda Barroso D; Schulte HL; Pires de Albuquerque C; Teles de Gois E; Salmen Espindola L; Martins Santana J; Marques Dourado Bastos I; Nunes de Araujo C; Henrique da Mota LM; Toledo Nobrega O; Martins Gomes C
  • Am J Trop Med Hyg 2021[Apr]; 104 (6): 2190-2194 PMID33819170show ga
  • Experts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the first peak of the COVID-19 epidemic in Brazil and analyzed the expressions of genes encoding interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-12A, IL-12B, and tumor necrosis factor-alpha in peripheral blood mononuclear cells. We included 64 leprosy patients and 50 controls. Twelve of the leprosy patients and 14 of the controls had been diagnosed with COVID-19. Co-infection was associated with increased IL-6 (P = 0.043) and IL-12B (P = 0.017) expression. The median disability grades were higher for leprosy/COVID-19 patients; however, the difference was not significant (P = 0.194). Patients co-infected with M. leprae and SARS-CoV-2 may experience a higher-grade proinflammatory state.
  • |Adult[MESH]
  • |COVID-19/complications/*immunology/metabolism[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Female[MESH]
  • |Gene Expression Regulation/immunology[MESH]
  • |Humans[MESH]
  • |Interleukin-12/genetics/*metabolism[MESH]
  • |Interleukin-6/genetics/*metabolism[MESH]
  • |Leprosy/*complications[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]


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