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10.1111/crj.13369

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33818909!8250518!33818909
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suck abstract from ncbi


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pmid33818909      Clin+Respir+J 2021 ; 15 (7): 815-825
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  • Clinical and etiological analysis of co-infections and secondary infections in COVID-19 patients: An observational study #MMPMID33818909
  • Chen S; Zhu Q; Xiao Y; Wu C; Jiang Z; Liu L; Qu J
  • Clin Respir J 2021[Jul]; 15 (7): 815-825 PMID33818909show ga
  • BACKGROUND: Co-infections, secondary bacterial or fungal infections, are important risk factors for poor outcomes in viral infections. The prevalence of co-infection and secondary infection in patients infected with SARS-CoV-2 is not well understood. AIMS: To investigate the role of co-infections and secondary infections in disease severity of hospitalized individuals with COVID-19. MATERIALS AND METHODS: A retrospective study was carried out between 11 January 2020 and 1 March 2020 among 408 laboratory confirmed COVID-19 patients in China. These patients were divided into three groups based on disease severity: mild or moderate, severe, or critically ill. Microbiological pathogens in blood, urine, and respiratory tract specimens were detected by the combination of culture, serology, polymerase chain reaction, and metagenomic next-generation sequencing (mNGS). RESULTS: The median age of participants was 48 years (IQR 34-60 years). Fifty-two patients (12.7%) had at least one additional pathogen, 8.1% were co-infected, and 5.1% had a secondary infection. There were 13 Mycoplasma pneumoniae cases, 8 Haemophilus influenzae cases, 8 respiratory viruses, and 3 Streptococcus pneumoniae cases, primarily detected in mild and moderate COVID-19 patients. Hospital-acquired infection pathogens were more common in critically ill patients. Compared to those without additional pathogens, patients with co-infections and/or secondary infections were more likely to receive antibiotics (p < 0.001) and have elevated levels of d-dimer (p = 0.0012), interleukin-6 (p = 0.0027), and procalcitonin (p = 0.0002). The performance of conventional culture was comparable with that of mNGS in diagnosis of secondary infections. CONCLUSION: Co-infections and secondary infections existed in hospitalized COVID-19 patients and were relevant to the disease severity. Screening of common respiratory pathogens and hospital infection control should be strengthened.
  • |*COVID-19[MESH]
  • |*Coinfection/epidemiology[MESH]
  • |*Virus Diseases[MESH]
  • |Adult[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]


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