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10.1002/cbin.11609 http://scihub22266oqcxt.onion/10.1002/cbin.11609 33818861!8251464!33818861     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33818861&cmd=llinks): Failed to open stream: HTTP request failed! 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The role of autophagy in controlling SARS-CoV-2 infection: An overview on virophagy-mediated molecular drug targets |pdf=|usr=}}{{33818861}} gab.com Text The role of autophagy in controlling SARS-CoV-2 infection: An overview on virophagy-mediated molecular drug targets JO: Cell Biol Int http://www.kidney.de/pget.php?&tw=1&pmid=33818861 #FOAvip Autophagy-dependent cell death is a prominent mechanism that majorly contributes to homeostasis by maintaining the turnover of organelles under stressful conditions. Several viruses, including coronaviruses (CoVs), take advantage of cellular autophagy to facilitate their own replication. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-coronavirus (beta-CoVs) that mediates its replication through a dependent or independent ATG5 pathway using specific double-membrane vesicles that can be considered as similar to autophagosomes. With due attention to several mutations in NSP6, a nonstructural protein with a positive regulatory effect on autophagosome formation, a potential correlation between SARS-CoV-2 pathogenesis mechanisms and autophagy can be expected. Certain medications, albeit limited in number, have been indicated to negatively regulate autophagy flux, potentially in a way similar to the inhibitory effect of beta-CoVs on the process of autophagy. However, there is no conclusive evidence to support their direct antagonizing effect on CoVs. Off-target accumulation of a major fraction of FDA-approved autophagy modulating drugs may result in adverse effects. Therefore, medications that have modulatory effects on autophagy could be considered as potential lead compounds for the development of new treatments against this virus. This review discusses the role of autophagy/virophagy in controlling SARS-CoV-2, focusing on the potential therapeutic implications. Twit Text FOAVip The role of autophagy in controlling SARS-CoV-2 infection: An overview on virophagy-mediated molecular drug targets ????Cell Biol Int http://www.kidney.de/pget.php?&tw=1&pmid=33818861 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33818861 #FOAvip English Wikipedia <ref>{{Cite pmid|33818861}}</ref> The role of autophagy in controlling SARS-CoV-2 infection: An overview on virophagy-mediated molecular drug targets #MMPMID33818861 Sargazi S; Sheervalilou R; Rokni M; Shirvaliloo M; Shahraki O; Rezaei N Cell Biol Int 2021[Aug]; 45 (8): 1599-1612 PMID33818861show ga Autophagy-dependent cell death is a prominent mechanism that majorly contributes to homeostasis by maintaining the turnover of organelles under stressful conditions. Several viruses, including coronaviruses (CoVs), take advantage of cellular autophagy to facilitate their own replication. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-coronavirus (beta-CoVs) that mediates its replication through a dependent or independent ATG5 pathway using specific double-membrane vesicles that can be considered as similar to autophagosomes. With due attention to several mutations in NSP6, a nonstructural protein with a positive regulatory effect on autophagosome formation, a potential correlation between SARS-CoV-2 pathogenesis mechanisms and autophagy can be expected. Certain medications, albeit limited in number, have been indicated to negatively regulate autophagy flux, potentially in a way similar to the inhibitory effect of beta-CoVs on the process of autophagy. However, there is no conclusive evidence to support their direct antagonizing effect on CoVs. Off-target accumulation of a major fraction of FDA-approved autophagy modulating drugs may result in adverse effects. Therefore, medications that have modulatory effects on autophagy could be considered as potential lead compounds for the development of new treatments against this virus. This review discusses the role of autophagy/virophagy in controlling SARS-CoV-2, focusing on the potential therapeutic implications. |*Autophagy[MESH] |COVID-19/*etiology/immunology/*prevention & control[MESH] |Drug Delivery Systems[MESH] |Humans[MESH]The role of autophagy in controlling SARS-CoV-2 infection: An overview(epmc).pdf DeepDyve Pubget Overpricing