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10.1007/s40618-021-01566-9

http://scihub22266oqcxt.onion/10.1007/s40618-021-01566-9
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33818731!8020370!33818731
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suck abstract from ncbi


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pmid33818731      J+Endocrinol+Invest 2021 ; 44 (12): 2601-2607
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  • Retrospective analysis of vitamin D status on inflammatory markers and course of the disease in patients with COVID-19 infection #MMPMID33818731
  • Unsal YA; Gul OO; Cander S; Ersoy C; Aydemir E; Ates C; Uzun Z; Armagan E; Unsal O; Erturk E
  • J Endocrinol Invest 2021[Dec]; 44 (12): 2601-2607 PMID33818731show ga
  • PURPOSE: The aim of the study was to investigate the association between serum 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection and parameters of immune function and clinical outcomes. METHODS: Fifty-six patients, who were admitted to the emergency clinic and diagnosed with COVID-19 infection, were included in the study. Data on clinical characteristics, inflammatory parameters and vitamin D status were recorded for each patient. All the participants had data on 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection. RESULTS: The patients were stratified as those with vitamin D status less than 20 ng/mL and higher than 20 ng/mL. A group with vitamin D status less than 20 ng/mL had lower lymphocyte counts and lower haemoglobin levels that was statistically significant (respectively; p = 0.021, p = 0.035). Higher C-reactive protein (CRP) levels were seen in the vitamin D-deficient group (p = 0.013). It was observed that vitamin D status of the patients who required oxygen therapy were lower than those who did not require oxygen therapy, not statistically significant (p = 0.05). Patients who did not use vitamin D supplementation within 6 months prior to COVID-19 infection had more likely to be diagnosed with pneumonia (p = 0.004). CONCLUSION: Cases with lower vitamin D status had increased inflammatory markers and worse clinical outcomes than patients with higher vitamin D status. This study suggests that vitamin D status can be used as a prognostic factor in COVID-19 patients, and vitamin D supplementation can be recommended to improve the clinical outcomes in COVID-19 infection.
  • |*Nutritional Status[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19/*blood/complications/immunology[MESH]
  • |Comorbidity[MESH]
  • |Dietary Supplements[MESH]
  • |Female[MESH]
  • |Hemoglobins/metabolism[MESH]
  • |Humans[MESH]
  • |Lymphocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Oxygen Inhalation Therapy[MESH]
  • |Pneumonia/complications/epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |Treatment Outcome[MESH]
  • |Vitamin D Deficiency/*blood/complications/immunology[MESH]


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