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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Endocrinol+Invest 2021 ; 44 (12): 2601-2607 Nephropedia Template TP
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Retrospective analysis of vitamin D status on inflammatory markers and course of the disease in patients with COVID-19 infection #MMPMID33818731
Unsal YA; Gul OO; Cander S; Ersoy C; Aydemir E; Ates C; Uzun Z; Armagan E; Unsal O; Erturk E
J Endocrinol Invest 2021[Dec]; 44 (12): 2601-2607 PMID33818731show ga
PURPOSE: The aim of the study was to investigate the association between serum 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection and parameters of immune function and clinical outcomes. METHODS: Fifty-six patients, who were admitted to the emergency clinic and diagnosed with COVID-19 infection, were included in the study. Data on clinical characteristics, inflammatory parameters and vitamin D status were recorded for each patient. All the participants had data on 25-hydroxyvitamin D status within the last 6 months prior to COVID-19 infection. RESULTS: The patients were stratified as those with vitamin D status less than 20 ng/mL and higher than 20 ng/mL. A group with vitamin D status less than 20 ng/mL had lower lymphocyte counts and lower haemoglobin levels that was statistically significant (respectively; p = 0.021, p = 0.035). Higher C-reactive protein (CRP) levels were seen in the vitamin D-deficient group (p = 0.013). It was observed that vitamin D status of the patients who required oxygen therapy were lower than those who did not require oxygen therapy, not statistically significant (p = 0.05). Patients who did not use vitamin D supplementation within 6 months prior to COVID-19 infection had more likely to be diagnosed with pneumonia (p = 0.004). CONCLUSION: Cases with lower vitamin D status had increased inflammatory markers and worse clinical outcomes than patients with higher vitamin D status. This study suggests that vitamin D status can be used as a prognostic factor in COVID-19 patients, and vitamin D supplementation can be recommended to improve the clinical outcomes in COVID-19 infection.
|*Nutritional Status[MESH]
|Adult[MESH]
|Aged[MESH]
|C-Reactive Protein/analysis[MESH]
|COVID-19/*blood/complications/immunology[MESH]
|Comorbidity[MESH]
|Dietary Supplements[MESH]
|Female[MESH]
|Hemoglobins/metabolism[MESH]
|Humans[MESH]
|Lymphocyte Count[MESH]
|Male[MESH]
|Middle Aged[MESH]
|Oxygen Inhalation Therapy[MESH]
|Pneumonia/complications/epidemiology[MESH]
|Retrospective Studies[MESH]
|Treatment Outcome[MESH]
|Vitamin D Deficiency/*blood/complications/immunology[MESH]