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10.1177/1358863X21995566

http://scihub22266oqcxt.onion/10.1177/1358863X21995566
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33818197!8024143!33818197
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suck abstract from ncbi


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pmid33818197      Vasc+Med 2021 ; 26 (4): 415-425
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  • Venous thromboembolism in COVID-19: A systematic review and meta-analysis #MMPMID33818197
  • Kollias A; Kyriakoulis KG; Lagou S; Kontopantelis E; Stergiou GS; Syrigos K
  • Vasc Med 2021[Aug]; 26 (4): 415-425 PMID33818197show ga
  • Severe coronavirus disease 2019 (COVID-19) is associated with increased risk of venous thromboembolism events (VTE). This study performed a systematic review in PubMed/EMBASE of studies reporting the prevalence of VTE in patients with COVID-19 who were totally screened/assessed for deep vein thrombosis (DVT) and/or for pulmonary embolism (PE). Among 47 candidate studies (n = 6459; 33 in Europe), 17 studies (n = 3973; weighted age 63.0 years, males 60%, intensive care unit (ICU) 16%) reported the prevalence of PE with a pooled estimate of 32% (95% CI: 25, 40%), and 32 studies (n = 2552; weighted age 62.6 years, males 57%, ICU 49%) reported the prevalence of DVT with a pooled estimate of 27% (95% CI: 21, 34%). A total of 36 studies reported the use of at least prophylactic antithrombotic treatment in the majority of their patients. Meta-regression analysis showed that the prevalence of VTE was higher across studies with a higher percentage of ICU patients and higher study population mean D-dimer values, and lower in studies with mixed dosing of anticoagulation in ? 50% of the population compared to studies with standard prophylactic dosing of anticoagulation in < 50% of the population. The pooled odds ratio for death in patients with COVID-19 and VTE versus those without VTE (17 studies, n = 2882) was 2.1 (95% CI: 1.2, 3.6). Hospitalized patients with severe COVID-19 are at high VTE risk despite prophylactic anticoagulation. Further research should investigate the individualized VTE risk of patients with COVID-19 and the optimal preventive antithrombotic therapy. PROSPERO Registration No.: CRD42020185543.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/diagnosis/*epidemiology/mortality[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prevalence[MESH]
  • |Prognosis[MESH]
  • |Pulmonary Embolism/diagnosis/*epidemiology/mortality[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]
  • |Venous Thromboembolism/diagnosis/*epidemiology/mortality[MESH]
  • |Venous Thrombosis/diagnosis/*epidemiology/mortality[MESH]


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