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10.1183/23120541.00077-2021

http://scihub22266oqcxt.onion/10.1183/23120541.00077-2021
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suck abstract from ncbi


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pmid33816594      ERJ+Open+Res 2021 ; 7 (1): ä
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  • A double-blind randomised controlled trial of protein supplementation to enhance exercise capacity in COPD during pulmonary rehabilitation: a pilot study #MMPMID33816594
  • Aldhahir AM; Aldabayan YS; Alqahtani JS; Ridsdale HA; Smith C; Hurst JR; Mandal S
  • ERJ Open Res 2021[Jan]; 7 (1): ä PMID33816594show ga
  • BACKGROUND: Pulmonary rehabilitation is a cost-effective management strategy in chronic obstructive pulmonary disease (COPD) which improves exercise performance and health-related quality of life. Nutritional supplementation may counter malnutrition and enhance pulmonary rehabilitation outcomes but rigorous evidence is absent. We aimed to investigate the effect of high-protein supplementation (Fortisip Compact Protein (FCP)) during pulmonary rehabilitation on exercise capacity. METHODS: This was a double-blind randomised controlled trial comparing FCP (intervention) with PreOp (a carbohydrate control supplement) in COPD patients participating in a pulmonary rehabilitation programme. Participants consumed the supplement twice a day during pulmonary rehabilitation and attended twice-weekly pulmonary rehabilitation sessions, with pre- and post-pulmonary rehabilitation measurements, including the incremental shuttle walk test (ISWT) distance at 6 weeks as the primary outcome. Participants' experience using supplements was assessed. RESULTS: 68 patients were recruited (intervention n=36 and control n=32). The trial was stopped early due to the COVID-19 pandemic. Although statistical significance was not reached, there was the suggestion of a clinically meaningful difference in the ISWT distance at 6 weeks favouring the intervention group (intervention 342+/-149 m (n=22) versus control 305+/-148 m (n=22); p=0.1). Individuals who achieved an improvement in the ISWT had a larger mid-thigh circumference at baseline (responders 62+/-4 cm versus nonresponders 55+/-6 cm; p=0.006). 79% of the patients were satisfied with the taste and 43% would continue taking the FCP. CONCLUSIONS: Although the data did not demonstrate a statistically significant difference in the ISWT, high-protein supplementation in COPD during pulmonary rehabilitation may result in a clinically meaningful improvement in exercise capacity and was acceptable to patients. Large, adequately powered studies are justified.
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