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10.3389/fcell.2021.640456 http://scihub22266oqcxt.onion/10.3389/fcell.2021.640456 33816489!8012536!33816489     free     free     free       Front+Cell+Dev+Biol 2021 ; 9 (ä): 640456 Nephropedia Template TP {{tp|p=33816489|t=2021. Exploiting Connections for Viral Replication |pdf=|usr=}}{{33816489}} gab.com Text Exploiting Connections for Viral Replication JO: Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=33816489 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 (coronavirus disease 2019) pandemic, is a positive strand RNA (+RNA) virus. Like other +RNA viruses, SARS-CoV-2 is dependent on host cell metabolic machinery to survive and replicate, remodeling cellular membranes to generate sites of viral replication. Viral RNA-containing double-membrane vesicles (DMVs) are a striking feature of +RNA viral replication and are abundant in SARS-CoV-2-infected cells. Their generation involves rewiring of host lipid metabolism, including lipid biosynthetic pathways. Viruses can also redirect lipids from host cell organelles; lipid exchange at membrane contact sites, where the membranes of adjacent organelles are in close apposition, has been implicated in the replication of several +RNA viruses. Here we review current understanding of DMV biogenesis. With a focus on the exploitation of contact site machinery by +RNA viruses to generate replication organelles, we discuss evidence that similar mechanisms support SARS-CoV-2 replication, protecting its RNA from the host cell immune response. Twit Text FOAVip Exploiting Connections for Viral Replication ????Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=33816489 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33816489 #FOAvip English Wikipedia <ref>{{Cite pmid|33816489}}</ref> Exploiting Connections for Viral Replication #MMPMID33816489 Wong LH; Edgar JR; Martello A; Ferguson BJ; Eden ER Front Cell Dev Biol 2021[]; 9 (ä): 640456 PMID33816489show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 (coronavirus disease 2019) pandemic, is a positive strand RNA (+RNA) virus. Like other +RNA viruses, SARS-CoV-2 is dependent on host cell metabolic machinery to survive and replicate, remodeling cellular membranes to generate sites of viral replication. Viral RNA-containing double-membrane vesicles (DMVs) are a striking feature of +RNA viral replication and are abundant in SARS-CoV-2-infected cells. Their generation involves rewiring of host lipid metabolism, including lipid biosynthetic pathways. Viruses can also redirect lipids from host cell organelles; lipid exchange at membrane contact sites, where the membranes of adjacent organelles are in close apposition, has been implicated in the replication of several +RNA viruses. Here we review current understanding of DMV biogenesis. With a focus on the exploitation of contact site machinery by +RNA viruses to generate replication organelles, we discuss evidence that similar mechanisms support SARS-CoV-2 replication, protecting its RNA from the host cell immune response. äExploiting Connections for Viral Replication (epmc).pdf DeepDyve Pubget Overpricing