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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Pharm+Anal 2021 ; 11 (3): 257-264 Nephropedia Template TP
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Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection #MMPMID33815862
Jiang C; Li X; Ge C; Ding Y; Zhang T; Cao S; Meng L; Lu S
J Pharm Anal 2021[Jun]; 11 (3): 257-264 PMID33815862show ga
Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year. With the expanding second wave of the pandemic in winter, the continuous evolution of SARS-CoV-2 has brought new issues, including the significance of virus mutations in infection and the detection of asymptomatic infection. In this review, we first introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19, primarily focusing on their strengths and limitations. We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection. The review finally summarized useful insights into the molecular diagnosis of COVID-19 under the special situation being challenged by virus mutation and asymptomatic infection.