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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Respirol+Case+Rep 2021 ; 9 (5): e00744 Nephropedia Template TP
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Nintedanib treatment for pulmonary fibrosis after coronavirus disease 2019 #MMPMID33815804
Ogata H; Nakagawa T; Sakoda S; Ishimatsu A; Taguchi K; Kadowaki M; Moriwaki A; Yoshida M
Respirol Case Rep 2021[May]; 9 (5): e00744 PMID33815804show ga
A 78-year-old Japanese woman with no smoking history suffered from near-fatal coronavirus disease 2019 (COVID-19) requiring four-week invasive mechanical ventilation, with subsequent radiological features of pulmonary fibrosis. Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy. In parallel with tapering systemic steroid, the patient was treated with nintedanib. Three months later, the patient was able to walk with a walking aid using oxygen at 4 L/min. The present case is an indication that nintedanib might provide a novel therapeutic approach for managing post-COVID-19 fibrosis, although further studies are warranted.