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10.1016/j.csbj.2021.03.025 http://scihub22266oqcxt.onion/10.1016/j.csbj.2021.03.025 33815686!7997051!33815686     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Comput+Struct+Biotechnol+J 2021 ; 19 (ä): 1889-1895 Nephropedia Template TP {{tp|p=33815686|t=2021. Neuropilins: C-end rule peptides and their association with nociception and COVID-19 |pdf=|usr=}}{{33815686}} gab.com Text Neuropilins: C-end rule peptides and their association with nociception and COVID-19 JO: Comput Struct Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=33815686 #FOAvip Viral internalization is aided by host cell surface receptors. In the case of SARS-CoV-2 and SARS-CoV, the primary host receptor is the angiotensin-converting enzyme 2 (ACE2). Considering the disparities in the transmission rate and viral tropism of the two coronaviruses, additional host factors were suspected. Recently, a novel host factor for SARS-CoV-2 entry, neuropilin-1 (NRP-1) has been identified. These receptors potentiate viral infection in the presence of other host factors like ACE2. Through its C-end rule (CendR) motif exposed following furin processing, the SARS-CoV-2 spike protein binds to the CendR pocket of NRP-1 and achieves cell entry through endocytosis. The binding of SARS-CoV-2 spike protein to the NRP-1 receptor interferes with the docking of its endogenous ligand VEGF-A, signaling that would otherwise promote nociception. This review looks at the function of neuropilins and how it contributes to SARS-CoV-2 infection and nociception. Twit Text FOAVip Neuropilins: C-end rule peptides and their association with nociception and COVID-19 ????Comput Struct Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=33815686 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33815686 #FOAvip English Wikipedia <ref>{{Cite pmid|33815686}}</ref> Neuropilins: C-end rule peptides and their association with nociception and COVID-19 #MMPMID33815686 Jobe A; Vijayan R Comput Struct Biotechnol J 2021[]; 19 (ä): 1889-1895 PMID33815686show ga Viral internalization is aided by host cell surface receptors. In the case of SARS-CoV-2 and SARS-CoV, the primary host receptor is the angiotensin-converting enzyme 2 (ACE2). Considering the disparities in the transmission rate and viral tropism of the two coronaviruses, additional host factors were suspected. Recently, a novel host factor for SARS-CoV-2 entry, neuropilin-1 (NRP-1) has been identified. These receptors potentiate viral infection in the presence of other host factors like ACE2. Through its C-end rule (CendR) motif exposed following furin processing, the SARS-CoV-2 spike protein binds to the CendR pocket of NRP-1 and achieves cell entry through endocytosis. The binding of SARS-CoV-2 spike protein to the NRP-1 receptor interferes with the docking of its endogenous ligand VEGF-A, signaling that would otherwise promote nociception. This review looks at the function of neuropilins and how it contributes to SARS-CoV-2 infection and nociception. äNeuropilins: C-end rule peptides and their association with nociceptio(epmc).pdf DeepDyve Pubget Overpricing