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10.1016/j.mayocp.2021.01.021

http://scihub22266oqcxt.onion/10.1016/j.mayocp.2021.01.021
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33814092!7859712!33814092
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suck abstract from ncbi


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pmid33814092      Mayo+Clin+Proc 2021 ; 96 (4): 921-931
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  • Obesity is a Major Risk Factor for Hospitalization in Community-Managed COVID-19 Pneumonia #MMPMID33814092
  • Cottini M; Lombardi C; Berti A
  • Mayo Clin Proc 2021[Apr]; 96 (4): 921-931 PMID33814092show ga
  • OBJECTIVE: We aimed to investigate whether the stratification of outpatients with coronavirus disease 2019 (COVID-19) pneumonia by body mass index (BMI) can help predict hospitalization and other severe outcomes. PATIENTS AND METHODS: We prospectively collected consecutive cases of community-managed COVID-19 pneumonia from March 1 to April 20, 2020, in the province of Bergamo and evaluated the association of overweight (25 kg/m(2) /=30 kg/m(2)) with time to hospitalization (primary end point), low-flow domiciliary oxygen need, noninvasive mechanical ventilation, intubation, and death due to COVID-19 (secondary end points) in this cohort. We analyzed the primary end point using multivariable Cox models. RESULTS: Of 338 patients included, 133 (39.4%) were overweight and 77 (22.8%) were obese. Age at diagnosis was younger in obese patients compared with those overweight or with normal weight (P<.001), whereas diabetes, dyslipidemia, and heart diseases were differently distributed among BMI categories. Azithromycin, hydroxychloroquine, and prednisolone use were similar between BMI categories (P>.05). Overall, 105 (31.1%) patients were hospitalized, and time to hospitalization was significantly shorter for obese vs over- or normal-weight patients (P<.001). In the final multivariable analysis, obese patients were more likely to require hospitalization than nonobese patients (hazard ratio, 5.83; 95% CI, 3.91 to 8.71). Results were similar in multiple sensitivity analyses. Low-flow domiciliary oxygen need, hospitalization with noninvasive mechanical ventilation, intubation, and death were significantly associated with obesity (P<.001). CONCLUSION: In patients with community-managed COVID-19 pneumonia, obesity is associated with a higher hospitalization risk and overall worse outcomes than for nonobese patients.
  • |*COVID-19/epidemiology/therapy[MESH]
  • |*Community Health Services/methods/statistics & numerical data[MESH]
  • |*Obesity/diagnosis/epidemiology[MESH]
  • |*Pneumonia, Viral/etiology/mortality/therapy[MESH]
  • |Age Factors[MESH]
  • |Body Mass Index[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Italy/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Outcome and Process Assessment, Health Care[MESH]
  • |Proportional Hazards Models[MESH]
  • |Risk Assessment/methods[MESH]
  • |Risk Factors[MESH]


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