Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.jinorgbio.2021.111423 http://scihub22266oqcxt.onion/10.1016/j.jinorgbio.2021.111423 33813307!7955571!33813307     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Inorg+Biochem 2021 ; 219 (ä): 111423 Nephropedia Template TP {{tp|p=33813307|t=2021. A SARS-CoV-2 -human metalloproteome interaction map |pdf=|usr=}}{{33813307}} gab.com Text A SARS-CoV-2 -human metalloproteome interaction map JO: J Inorg Biochem http://www.kidney.de/pget.php?&tw=1&pmid=33813307 #FOAvip The recent pandemic caused by the novel coronavirus resulted in the greatest global health crisis since the Spanish flu pandemic of 1918. There is limited knowledge of whether SARS-CoV-2 is physically associated with human metalloproteins. Recently, high-confidence, experimentally supported protein-protein interactions between SARS-CoV-2 and human proteins were reported. In this work, 58 metalloproteins among these human targets have been identified by a structure-based approach. This study reveals that most human metalloproteins interact with the recently discovered SARS-CoV-2 orf8 protein, whose antibodies are one of the principal markers of SARS-CoV-2 infections. Furthermore, this work provides sufficient evidence to conclude that Zn(2+) plays an important role in the interplay between the novel coronavirus and humans. First, the content of Zn-binding proteins in the involved human metalloproteome is significantly higher than that of the other metal ions. Second, a molecular linkage between the identified human Zn-binding proteome with underlying medical conditions, that might increase the risk of severe illness from the SARS-CoV-2 virus, has been found. Likely perturbations of host cellular metal homeostasis by SARS-CoV-2 infection are highlighted. Twit Text FOAVip A SARS-CoV-2 -human metalloproteome interaction map ????J Inorg Biochem http://www.kidney.de/pget.php?&tw=1&pmid=33813307 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33813307 #FOAvip English Wikipedia <ref>{{Cite pmid|33813307}}</ref> A SARS-CoV-2 -human metalloproteome interaction map #MMPMID33813307 Chasapis CT; Georgiopoulou AK; Perlepes SP; Bjorklund G; Peana M J Inorg Biochem 2021[Jun]; 219 (ä): 111423 PMID33813307show ga The recent pandemic caused by the novel coronavirus resulted in the greatest global health crisis since the Spanish flu pandemic of 1918. There is limited knowledge of whether SARS-CoV-2 is physically associated with human metalloproteins. Recently, high-confidence, experimentally supported protein-protein interactions between SARS-CoV-2 and human proteins were reported. In this work, 58 metalloproteins among these human targets have been identified by a structure-based approach. This study reveals that most human metalloproteins interact with the recently discovered SARS-CoV-2 orf8 protein, whose antibodies are one of the principal markers of SARS-CoV-2 infections. Furthermore, this work provides sufficient evidence to conclude that Zn(2+) plays an important role in the interplay between the novel coronavirus and humans. First, the content of Zn-binding proteins in the involved human metalloproteome is significantly higher than that of the other metal ions. Second, a molecular linkage between the identified human Zn-binding proteome with underlying medical conditions, that might increase the risk of severe illness from the SARS-CoV-2 virus, has been found. Likely perturbations of host cellular metal homeostasis by SARS-CoV-2 infection are highlighted. |COVID-19/metabolism[MESH] |Carrier Proteins/metabolism[MESH] |Host-Pathogen Interactions/*physiology[MESH] |Humans[MESH] |Metalloproteins/genetics/*metabolism[MESH] |Nervous System Diseases/*genetics[MESH] |SARS-CoV-2/metabolism/*pathogenicity[MESH]A SARS-CoV-2 -human metalloproteome interaction map (epmc).pdf DeepDyve Pubget Overpricing