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10.1016/j.bbrc.2021.03.096 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2021.03.096 33813272!7997389!33813272     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2021 ; 555 (ä): 134-139 Nephropedia Template TP {{tp|p=33813272|t=2021. ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model |pdf=|usr=}}{{33813272}} gab.com Text ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=33813272 #FOAvip There is an urgent need for antivirals targeting the SARS-CoV-2 virus to fight the current COVID-19 pandemic. The SARS-CoV-2 main protease (3CLpro) represents a promising target for antiviral therapy. The lack of selectivity for some of the reported 3CLpro inhibitors, specifically versus cathepsin L, raises potential safety and efficacy concerns. ALG-097111 potently inhibited SARS-CoV-2 3CLpro (IC(50) = 7 nM) without affecting the activity of human cathepsin L (IC(50) > 10 muM). When ALG-097111 was dosed in hamsters challenged with SARS-CoV-2, a robust and significant 3.5 log(10) (RNA copies/mg) reduction of the viral RNA copies and 3.7 log(10) (TCID(50)/mg) reduction in the infectious virus titers in the lungs was observed. These results provide the first in vivo validation for the SARS-CoV-2 3CLpro as a promising therapeutic target for selective small molecule inhibitors. Twit Text FOAVip ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=33813272 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33813272 #FOAvip English Wikipedia <ref>{{Cite pmid|33813272}}</ref> ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model #MMPMID33813272 Vandyck K; Abdelnabi R; Gupta K; Jochmans D; Jekle A; Deval J; Misner D; Bardiot D; Foo CS; Liu C; Ren S; Beigelman L; Blatt LM; Boland S; Vangeel L; Dejonghe S; Chaltin P; Marchand A; Serebryany V; Stoycheva A; Chanda S; Symons JA; Raboisson P; Neyts J Biochem Biophys Res Commun 2021[May]; 555 (ä): 134-139 PMID33813272show ga There is an urgent need for antivirals targeting the SARS-CoV-2 virus to fight the current COVID-19 pandemic. The SARS-CoV-2 main protease (3CLpro) represents a promising target for antiviral therapy. The lack of selectivity for some of the reported 3CLpro inhibitors, specifically versus cathepsin L, raises potential safety and efficacy concerns. ALG-097111 potently inhibited SARS-CoV-2 3CLpro (IC(50) = 7 nM) without affecting the activity of human cathepsin L (IC(50) > 10 muM). When ALG-097111 was dosed in hamsters challenged with SARS-CoV-2, a robust and significant 3.5 log(10) (RNA copies/mg) reduction of the viral RNA copies and 3.7 log(10) (TCID(50)/mg) reduction in the infectious virus titers in the lungs was observed. These results provide the first in vivo validation for the SARS-CoV-2 3CLpro as a promising therapeutic target for selective small molecule inhibitors. |*COVID-19 Drug Treatment[MESH] |*Disease Models, Animal[MESH] |Amides/pharmacokinetics/*pharmacology[MESH] |Animals[MESH] |COVID-19/virology[MESH] |Cathepsin L/antagonists & inhibitors[MESH] |Cell Line[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors[MESH] |Cricetinae[MESH] |Cysteine Proteinase Inhibitors/pharmacokinetics/*pharmacology[MESH] |Female[MESH] |Humans[MESH] |Inhibitory Concentration 50[MESH] |Male[MESH] |Mesocricetus/virology[MESH] |Reproducibility of Results[MESH] |SARS-CoV-2/*drug effects/*enzymology/growth & development[MESH] |Serine Endopeptidases[MESH] |Substrate Specificity[MESH]ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cyst(epmc).pdf DeepDyve Pubget Overpricing