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10.1016/j.virol.2021.03.015 http://scihub22266oqcxt.onion/10.1016/j.virol.2021.03.015 33813212!ä!33813212 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virology 2021 ; 559 (ä): 46-56 Nephropedia Template TP {{tp|p=33813212|t=2021. Porcine deltacoronavirus nsp10 antagonizes interferon-beta production independently of its zinc finger domains |pdf=|usr=}}{{33813212}} gab.com Text Porcine deltacoronavirus nsp10 antagonizes interferon-beta production independently of its zinc finger domains JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=33813212 #FOAvip Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes serious vomiting and diarrhea in piglets. Previous work demonstrated that PDCoV infection inhibits type I interferon (IFN) production. Here, we found that ectopic expression of PDCoV nsp10 significantly inhibited Sendai virus (SeV)-induced IFN-beta production by impairing the phosphorylation and nuclear translocation of two transcription factors, IRF3 and NF-kappaB p65 subunit. Interestingly, experiments with truncated mutants and site-directed mutagenesis revealed that PDCoV nsp10 mutants with missing or destroyed zinc fingers (ZFs) domains also impeded SeV-induced IFN-beta production, suggesting that nsp10 does not require its ZF domains to antagonize IFN-beta production. Further work found that co-expression of nsp10 with nsp14 or nsp16, two replicative enzymes, significantly enhanced the inhibitory effects of nsp10 on IFN-beta. Taken together, our results demonstrate that PDCoV nsp10 antagonizes IFN via a ZF-independent mechanism and has a synergistic effect with nsp14 and nsp16 on inhibiting IFN-beta production. Twit Text FOAVip Porcine deltacoronavirus nsp10 antagonizes interferon-beta production independently of its zinc finger domains ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=33813212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33813212 #FOAvip English Wikipedia <ref>{{Cite pmid|33813212}}</ref> Porcine deltacoronavirus nsp10 antagonizes interferon-beta production independently of its zinc finger domains #MMPMID33813212 Fang P; Hong Y; Xia S; Zhang J; Ren J; Zhou Y; Fang L; Xiao S Virology 2021[Jul]; 559 (ä): 46-56 PMID33813212show ga Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes serious vomiting and diarrhea in piglets. Previous work demonstrated that PDCoV infection inhibits type I interferon (IFN) production. Here, we found that ectopic expression of PDCoV nsp10 significantly inhibited Sendai virus (SeV)-induced IFN-beta production by impairing the phosphorylation and nuclear translocation of two transcription factors, IRF3 and NF-kappaB p65 subunit. Interestingly, experiments with truncated mutants and site-directed mutagenesis revealed that PDCoV nsp10 mutants with missing or destroyed zinc fingers (ZFs) domains also impeded SeV-induced IFN-beta production, suggesting that nsp10 does not require its ZF domains to antagonize IFN-beta production. Further work found that co-expression of nsp10 with nsp14 or nsp16, two replicative enzymes, significantly enhanced the inhibitory effects of nsp10 on IFN-beta. Taken together, our results demonstrate that PDCoV nsp10 antagonizes IFN via a ZF-independent mechanism and has a synergistic effect with nsp14 and nsp16 on inhibiting IFN-beta production. |Animals[MESH] |Cell Line[MESH] |Deltacoronavirus/*metabolism[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Interferon Regulatory Factor-3/metabolism[MESH] |Interferon-beta/*antagonists & inhibitors/metabolism[MESH] |Mutation[MESH] |Sendai virus/metabolism[MESH] |Signal Transduction[MESH] |Swine[MESH] |Transcription Factor RelA/metabolism[MESH] |Viral Nonstructural Proteins/chemistry/genetics/*metabolism[MESH]Porcine deltacoronavirus nsp10 antagonizes interferon-beta production (epmc).pdf DeepDyve Pubget Overpricing