Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ebiom.2021.103291 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2021.103291 33813139!8016444!33813139     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2021 ; 66 (ä): 103291 Nephropedia Template TP {{tp|p=33813139|t=2021. Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge |pdf=|usr=}}{{33813139}} gab.com Text Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=33813139 #FOAvip Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal. Twit Text FOAVip Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=33813139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33813139 #FOAvip English Wikipedia <ref>{{Cite pmid|33813139}}</ref> Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge #MMPMID33813139 Winkler MS; Skirecki T; Brunkhorst FM; Cajander S; Cavaillon JM; Ferrer R; Flohe SB; Garcia-Salido A; Giamarellos-Bourboulis EJ; Girardis M; Kox M; Lachmann G; Martin-Loeches I; Netea MG; Spinetti T; Schefold JC; Torres A; Uhle F; Venet F; Weis S; Scherag A; Rubio I; Osuchowski MF EBioMedicine 2021[Apr]; 66 (ä): 103291 PMID33813139show ga Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal. |*COVID-19 Drug Treatment[MESH] |*COVID-19 Vaccines/pharmacology[MESH] |*Disease Models, Animal[MESH] |Age Factors[MESH] |Animals[MESH] |Antiviral Agents/pharmacology[MESH] |COVID-19/*etiology/physiopathology/therapy[MESH] |Clinical Trials as Topic[MESH] |Cricetinae[MESH] |Ferrets[MESH] |Humans[MESH] |Mice[MESH] |Mutation[MESH] |Primates[MESH]Bridging animal and clinical research during SARS-CoV-2 pandemic: A ne(epmc).pdf DeepDyve Pubget Overpricing