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10.1016/j.compbiomed.2021.104335

http://scihub22266oqcxt.onion/10.1016/j.compbiomed.2021.104335
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suck abstract from ncbi


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pmid33812263      Comput+Biol+Med 2021 ; 132 (ä): 104335
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  • Explaining machine learning based diagnosis of COVID-19 from routine blood tests with decision trees and criteria graphs #MMPMID33812263
  • Alves MA; Castro GZ; Oliveira BAS; Ferreira LA; Ramirez JA; Silva R; Guimaraes FG
  • Comput Biol Med 2021[May]; 132 (ä): 104335 PMID33812263show ga
  • The sudden outbreak of coronavirus disease 2019 (COVID-19) revealed the need for fast and reliable automatic tools to help health teams. This paper aims to present understandable solutions based on Machine Learning (ML) techniques to deal with COVID-19 screening in routine blood tests. We tested different ML classifiers in a public dataset from the Hospital Albert Einstein, Sao Paulo, Brazil. After cleaning and pre-processing the data has 608 patients, of which 84 are positive for COVID-19 confirmed by RT-PCR. To understand the model decisions, we introduce (i) a local Decision Tree Explainer (DTX) for local explanation and (ii) a Criteria Graph to aggregate these explanations and portrait a global picture of the results. Random Forest (RF) classifier achieved the best results (accuracy 0.88, F1-score 0.76, sensitivity 0.66, specificity 0.91, and AUROC 0.86). By using DTX and Criteria Graph for cases confirmed by the RF, it was possible to find some patterns among the individuals able to aid the clinicians to understand the interconnection among the blood parameters either globally or on a case-by-case basis. The results are in accordance with the literature and the proposed methodology may be embedded in an electronic health record system.
  • |*COVID-19[MESH]
  • |Brazil[MESH]
  • |Decision Trees[MESH]
  • |Hematologic Tests[MESH]
  • |Humans[MESH]
  • |Machine Learning[MESH]


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