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10.1016/j.celrep.2021.108959 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.108959 33811811!7985926!33811811     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 35 (1): 108959 Nephropedia Template TP {{tp|p=33811811|t=2021. Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2 |pdf=|usr=}}{{33811811}} gab.com Text Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2 JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33811811 #FOAvip There is an urgent need for antivirals to treat the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a repurposing library of approximately 3,000 drugs. Screening in Vero cells finds few antivirals, while screening in human Huh7.5 cells validates 23 diverse antiviral drugs. Extending our studies to lung epithelial cells, we find that there are major differences in drug sensitivity and entry pathways used by SARS-CoV-2 in these cells. Entry in lung epithelial Calu-3 cells is pH independent and requires TMPRSS2, while entry in Vero and Huh7.5 cells requires low pH and triggering by acid-dependent endosomal proteases. Moreover, we find nine drugs are antiviral in respiratory cells, seven of which have been used in humans, and three are US Food and Drug Administration (FDA) approved, including cyclosporine. We find that the antiviral activity of cyclosporine is targeting Cyclophilin rather than calcineurin, revealing essential host targets that have the potential for rapid clinical implementation. Twit Text FOAVip Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2 ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33811811 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33811811 #FOAvip English Wikipedia <ref>{{Cite pmid|33811811}}</ref> Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2 #MMPMID33811811 Dittmar M; Lee JS; Whig K; Segrist E; Li M; Kamalia B; Castellana L; Ayyanathan K; Cardenas-Diaz FL; Morrisey EE; Truitt R; Yang W; Jurado K; Samby K; Ramage H; Schultz DC; Cherry S Cell Rep 2021[Apr]; 35 (1): 108959 PMID33811811show ga There is an urgent need for antivirals to treat the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a repurposing library of approximately 3,000 drugs. Screening in Vero cells finds few antivirals, while screening in human Huh7.5 cells validates 23 diverse antiviral drugs. Extending our studies to lung epithelial cells, we find that there are major differences in drug sensitivity and entry pathways used by SARS-CoV-2 in these cells. Entry in lung epithelial Calu-3 cells is pH independent and requires TMPRSS2, while entry in Vero and Huh7.5 cells requires low pH and triggering by acid-dependent endosomal proteases. Moreover, we find nine drugs are antiviral in respiratory cells, seven of which have been used in humans, and three are US Food and Drug Administration (FDA) approved, including cyclosporine. We find that the antiviral activity of cyclosporine is targeting Cyclophilin rather than calcineurin, revealing essential host targets that have the potential for rapid clinical implementation. |*COVID-19 Drug Treatment[MESH] |*Drug Repositioning[MESH] |Animals[MESH] |COVID-19/metabolism/pathology[MESH] |Chlorocebus aethiops[MESH] |Cyclosporine/*pharmacology[MESH] |Epithelial Cells/*metabolism/pathology/virology[MESH] |Humans[MESH] |Lung/*metabolism/pathology/virology[MESH] |SARS-CoV-2/*metabolism[MESH] |Serine Endopeptidases/metabolism[MESH] |United States[MESH] |United States Food and Drug Administration[MESH]Drug repurposing screens reveal cell-type-specific entry pathways and (epmc).pdf DeepDyve Pubget Overpricing