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10.1002/jmv.26993 http://scihub22266oqcxt.onion/10.1002/jmv.26993 33811680!8250710!33811680     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (7): 4559-4563 Nephropedia Template TP {{tp|p=33811680|t=2021. Downregulation of type III interferons in patients with severe COVID-19 |pdf=|usr=}}{{33811680}} gab.com Text Downregulation of type III interferons in patients with severe COVID-19 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33811680 #FOAvip Coronavirus disease 2019 (COVID-19) is globally rampant, and to curb the growing burden of this disease, in-depth knowledge about its pathophysiology is needed. This was an observational study conducted at a single center to investigate serum cytokine and chemokine levels of COVID-19 patients, based on disease severity. We included 72 consecutive COVID-19 patients admitted to our hospital from March 21 to August 31, 2020. Patients were divided into Mild-Moderate I (mild) and Moderate II-Severe (severe) groups based on the COVID-19 severity classification developed by the Ministry of Health, Labor and Welfare (MHLW) of Japan. We compared the patient characteristics as well as the serum cytokine and chemokine levels on the day of admission between the two groups. Our findings indicated that the severe group had significantly higher levels of serum fibrinogen, d-dimer, lactate dehydrogenase, C-reactive protein, ferritin, Krebs von den Lungen-6, surfactant protein (SP)-D, and SP-A than the mild group. Strikingly, the levels of interleukin (IL)-28A/interferon (IFN)-lambda2 were significantly lower in the severe group than in the mild group. We believe that reduced levels of type III interferons (IFN-lambdas) and alterations in the levels of other cytokines and chemokines may impact the severity of the disease. Twit Text FOAVip Downregulation of type III interferons in patients with severe COVID-19 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33811680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33811680 #FOAvip English Wikipedia <ref>{{Cite pmid|33811680}}</ref> Downregulation of type III interferons in patients with severe COVID-19 #MMPMID33811680 Fukuda Y; Homma T; Inoue H; Onitsuka C; Ikeda H; Goto Y; Sato Y; Kimura T; Hirai K; Ohta S; Yamamoto M; Kusumoto S; Suzuki S; Tanaka A; Sagara H J Med Virol 2021[Jul]; 93 (7): 4559-4563 PMID33811680show ga Coronavirus disease 2019 (COVID-19) is globally rampant, and to curb the growing burden of this disease, in-depth knowledge about its pathophysiology is needed. This was an observational study conducted at a single center to investigate serum cytokine and chemokine levels of COVID-19 patients, based on disease severity. We included 72 consecutive COVID-19 patients admitted to our hospital from March 21 to August 31, 2020. Patients were divided into Mild-Moderate I (mild) and Moderate II-Severe (severe) groups based on the COVID-19 severity classification developed by the Ministry of Health, Labor and Welfare (MHLW) of Japan. We compared the patient characteristics as well as the serum cytokine and chemokine levels on the day of admission between the two groups. Our findings indicated that the severe group had significantly higher levels of serum fibrinogen, d-dimer, lactate dehydrogenase, C-reactive protein, ferritin, Krebs von den Lungen-6, surfactant protein (SP)-D, and SP-A than the mild group. Strikingly, the levels of interleukin (IL)-28A/interferon (IFN)-lambda2 were significantly lower in the severe group than in the mild group. We believe that reduced levels of type III interferons (IFN-lambdas) and alterations in the levels of other cytokines and chemokines may impact the severity of the disease. |Adult[MESH] |Aged[MESH] |C-Reactive Protein/analysis[MESH] |COVID-19/*blood/pathology[MESH] |Chemokines/*blood[MESH] |Down-Regulation[MESH] |Female[MESH] |Ferritins/blood[MESH] |Fibrin Fibrinogen Degradation Products/analysis[MESH] |Fibrinogen/analysis[MESH] |Humans[MESH] |Interferon Lambda[MESH] |Interferons/biosynthesis/*blood[MESH] |Interleukins/blood[MESH] |L-Lactate Dehydrogenase/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Mucin-1/blood[MESH] |Pulmonary Surfactant-Associated Protein A/blood[MESH] |Pulmonary Surfactant-Associated Protein D/blood[MESH] |SARS-CoV-2/*immunology[MESH]Downregulation of type III interferons in patients with severe COVID-1(epmc).pdf DeepDyve Pubget Overpricing