Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s00005-021-00613-w http://scihub22266oqcxt.onion/10.1007/s00005-021-00613-w 33811524!8019082!33811524     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Immunol+Ther+Exp+(Warsz) 2021 ; 69 (1): 10 Nephropedia Template TP {{tp|p=33811524|t=2021. New Approaches to the Prevention and Treatment of Viral Diseases |pdf=|usr=}}{{33811524}} gab.com Text New Approaches to the Prevention and Treatment of Viral Diseases JO: Arch Immunol Ther Exp (Warsz) http://www.kidney.de/pget.php?&tw=1&pmid=33811524 #FOAvip The review discusses a new approach to the prevention and treatment of viral infections based on the use of pine needles polyprenyl phosphate (PPP) and associated with the infringement of prenylation process-the attachment of farnesol or geranyl geraniol to the viral protein. Currently, prenylation has been detected in type 1 adenovirus, hepatitis C virus, several herpes viruses, influenza virus, HIV. However, this list is far from complete, given that prenylated proteins play an extremely important role in the activity of the virus. We assume that the interferon produced in response to PPP may suppress expression of the SREBP2 transcription factor. As a result, the mevalonic acid pathway is violated and, as a result, the formation of early polyprenols precursors (geraniol, geranyl geraniol, farnesol), which are necessary for the prenylation of viral proteins, is blocked and the formation of mature, virulent virus particles is broken. As a consequence, the maturation of viral particles is inhibited, and defective particles are formed. Polyprenol was extracted from greenery (pine, fir and spruce needles, mulberry leaves, etc.), purified by chromatography, phosphorylated and identified by HPLC and NMR. Obtained PPP was used as antiviral in some experimental models in vitro and in vivo. During numerous studies, it was found that PPP manifested versatile antiviral effects, both in vitro and in vivo. The maximum effect was observed with viruses in which the presence of prenylated proteins was established, namely influenza A virus, HIV-1, tick-borne encephalitis virus, hepatitis A and C viruses, herpes simplex viruses type 1 and 2, some coronavirus. The available data obtained both in the experimental conditions and during clinical trials allow us to regard PPPs as safe and effective medicine for prevention and treatment of viral diseases. Twit Text FOAVip New Approaches to the Prevention and Treatment of Viral Diseases ????Arch Immunol Ther Exp (Warsz) http://www.kidney.de/pget.php?&tw=1&pmid=33811524 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33811524 #FOAvip English Wikipedia <ref>{{Cite pmid|33811524}}</ref> New Approaches to the Prevention and Treatment of Viral Diseases #MMPMID33811524 Pronin AV; Narovlyansky AN; Sanin AV Arch Immunol Ther Exp (Warsz) 2021[Apr]; 69 (1): 10 PMID33811524show ga The review discusses a new approach to the prevention and treatment of viral infections based on the use of pine needles polyprenyl phosphate (PPP) and associated with the infringement of prenylation process-the attachment of farnesol or geranyl geraniol to the viral protein. Currently, prenylation has been detected in type 1 adenovirus, hepatitis C virus, several herpes viruses, influenza virus, HIV. However, this list is far from complete, given that prenylated proteins play an extremely important role in the activity of the virus. We assume that the interferon produced in response to PPP may suppress expression of the SREBP2 transcription factor. As a result, the mevalonic acid pathway is violated and, as a result, the formation of early polyprenols precursors (geraniol, geranyl geraniol, farnesol), which are necessary for the prenylation of viral proteins, is blocked and the formation of mature, virulent virus particles is broken. As a consequence, the maturation of viral particles is inhibited, and defective particles are formed. Polyprenol was extracted from greenery (pine, fir and spruce needles, mulberry leaves, etc.), purified by chromatography, phosphorylated and identified by HPLC and NMR. Obtained PPP was used as antiviral in some experimental models in vitro and in vivo. During numerous studies, it was found that PPP manifested versatile antiviral effects, both in vitro and in vivo. The maximum effect was observed with viruses in which the presence of prenylated proteins was established, namely influenza A virus, HIV-1, tick-borne encephalitis virus, hepatitis A and C viruses, herpes simplex viruses type 1 and 2, some coronavirus. The available data obtained both in the experimental conditions and during clinical trials allow us to regard PPPs as safe and effective medicine for prevention and treatment of viral diseases. |Animals[MESH] |Antiviral Agents/*pharmacology/therapeutic use[MESH] |Clinical Trials as Topic[MESH] |Disease Models, Animal[MESH] |Gene Expression Regulation/drug effects/immunology[MESH] |Humans[MESH] |Interferons/metabolism[MESH] |Microscopy, Electron[MESH] |Pinus/*chemistry[MESH] |Polyisoprenyl Phosphates/*pharmacology/therapeutic use[MESH] |Protein Prenylation/*drug effects[MESH] |Sterol Regulatory Element Binding Protein 2/metabolism[MESH] |Treatment Outcome[MESH] |Viral Proteins/metabolism[MESH] |Virion/drug effects/ultrastructure[MESH] |Virus Diseases/*drug therapy/immunology/prevention & control[MESH]New Approaches to the Prevention and Treatment of Viral Diseases (epmc).pdf DeepDyve Pubget Overpricing