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10.3390/genes12030450 http://scihub22266oqcxt.onion/10.3390/genes12030450 33809949!8004236!33809949     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33809949.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+(Basel) 2021 ; 12 (3): ä Nephropedia Template TP {{tp|p=33809949|t=2021. A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 Infection |pdf=|usr=}}{{33809949}} gab.com Text A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 Infection JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33809949 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic has caused more than 2.3 million casualties worldwide and the lack of effective treatments is a major health concern. The development of targeted drugs is held back due to a limited understanding of the molecular mechanisms underlying the perturbation of cell physiology observed after viral infection. Recently, several approaches, aimed at identifying cellular proteins that may contribute to COVID-19 pathology, have been reported. Albeit valuable, this information offers limited mechanistic insight as these efforts have produced long lists of cellular proteins, the majority of which are not annotated to any cellular pathway. We have embarked in a project aimed at bridging this mechanistic gap by developing a new bioinformatic approach to estimate the functional distance between a subset of proteins and a list of pathways. A comprehensive literature search allowed us to annotate, in the SIGNOR 2.0 resource, causal information underlying the main molecular mechanisms through which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related coronaviruses affect the host-cell physiology. Next, we developed a new strategy that enabled us to link SARS-CoV-2 interacting proteins to cellular phenotypes via paths of causal relationships. Remarkably, the extensive information about inhibitors of signaling proteins annotated in SIGNOR 2.0 makes it possible to formulate new potential therapeutic strategies. The proposed approach, which is generally applicable, generated a literature-based causal network that can be used as a framework to formulate informed mechanistic hypotheses on COVID-19 etiology and pathology. Twit Text FOAVip A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 Infection ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=33809949 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33809949 #FOAvip English Wikipedia <ref>{{Cite pmid|33809949}}</ref> A Resource for the Network Representation of Cell Perturbations Caused by SARS-CoV-2 Infection #MMPMID33809949 Perfetto L; Micarelli E; Iannuccelli M; Lo Surdo P; Giuliani G; Latini S; Pugliese GM; Massacci G; Vumbaca S; Riccio F; Fuoco C; Paoluzi S; Castagnoli L; Cesareni G; Licata L; Sacco F Genes (Basel) 2021[Mar]; 12 (3): ä PMID33809949show ga The coronavirus disease 2019 (COVID-19) pandemic has caused more than 2.3 million casualties worldwide and the lack of effective treatments is a major health concern. The development of targeted drugs is held back due to a limited understanding of the molecular mechanisms underlying the perturbation of cell physiology observed after viral infection. Recently, several approaches, aimed at identifying cellular proteins that may contribute to COVID-19 pathology, have been reported. Albeit valuable, this information offers limited mechanistic insight as these efforts have produced long lists of cellular proteins, the majority of which are not annotated to any cellular pathway. We have embarked in a project aimed at bridging this mechanistic gap by developing a new bioinformatic approach to estimate the functional distance between a subset of proteins and a list of pathways. A comprehensive literature search allowed us to annotate, in the SIGNOR 2.0 resource, causal information underlying the main molecular mechanisms through which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related coronaviruses affect the host-cell physiology. Next, we developed a new strategy that enabled us to link SARS-CoV-2 interacting proteins to cellular phenotypes via paths of causal relationships. Remarkably, the extensive information about inhibitors of signaling proteins annotated in SIGNOR 2.0 makes it possible to formulate new potential therapeutic strategies. The proposed approach, which is generally applicable, generated a literature-based causal network that can be used as a framework to formulate informed mechanistic hypotheses on COVID-19 etiology and pathology. |*Signal Transduction/genetics[MESH] |Autophagy/*genetics[MESH] |COVID-19/genetics/*metabolism/pathology/*virology[MESH] |Gene Ontology[MESH] |Gene Regulatory Networks[MESH] |Host Microbial Interactions/*genetics[MESH] |Humans[MESH] |Inflammation/genetics/metabolism/virology[MESH] |Proteome[MESH] |PubMed[MESH]A Resource for the Network Representation of Cell Perturbations Caused(epmc).pdf DeepDyve Pubget Overpricing